摘要
Abstract
Objective To investigate effects of parathyroidectomy on coronary artery calcification (CAC) and calcium and phosphorus metabolism in patients with end-stage renal disease (ESRD) complicated by secondary hyperpar-athyroidism (SHPT). Methods Clinical data of 300 patients with ESRD complicated by SHPT undergoing selective par-athyroidectomy admitted during January 2006 and February 2016 was retrospectively analyzed, and the patients were di-vided into CAC group (n=210) and non CAC group (n=90) according to whether or not having CAC. Multiple factor Logistic regression analysis was used to analyze independent risk factors affecting CAC pathogenesy in patients with ESRD complicated by SHPT, the CAC accumulated points and changes of immunoreactive parathyroid hormone (IPTH), blood calcium, blood phosphorus, calcium-phosphorus product and triglyceride levels before and in 6 and 12 months after oper-ation were compared in all patients. Results Long dialysis time and high CAC accumulated points were independent risk factors affecting CAC pathogenesy in patients with ESRD complicated by SHPT (P<0. 05). In 6 and 12 months after op-eration, blood calcium, blood phosphorus, calcium-phosphorus product, triglyceride and IPTH levels and accumulated points were significantly lower than those before operation (P<0. 05). In 12 months after operation, values of IPTH level and CAC accumulated point were significantly lower than those in 6 months after operation (P<0. 05). Conclusion Parathyroidectomy may effectively improve calcium and phosphorus metabolic disturbance, reduce IPTH level and inhibit CAC progression in patients with ESRD complicated by SHPT.关键词
终末期肾病/甲状旁腺切除术/甲状旁腺功能亢进症,继发性/冠状动脉钙化Key words
End-stage renal disease/Parathyroidectomy/Hyperparathyroidism, secondary/Coronary artery cal-cification分类
医药卫生
