解放军医药杂志2018，Vol.30Issue(6)：68-71,4.DOI:10.3969/j.issn.2095-140X.2018.06.018
布拉酵母菌散对轮状病毒肠炎患儿血清和粪便IL-6、TNF-α及IFN-γ的影响
Effects of Saccharomyces Boulardii Sachets on Serum and Fecal IL-6, TNF-α and IFN-γ in Children with Rota-viral Enteritis
摘要
Abstract
Objective To observe effects of Saccharomyces Boulardii Sachets on serum and fecal interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in children with rotaviral enteritis. Methods A total of 118 children with rotaviral enteritis admitted during June 2015 and April 2017 were divided into study group and control group (n=59 for each group) according to different treatment methods. All patients received conventional treat-ment, and study group was added with Saccharomyces Boulardii Sachets on the basis of conventional treatment, and all patients were treated for 3 d. In two groups, serum and fecal IL-6, TNF-α and IFN-γ levels were observed before and af-ter treatment, and clinical efficacy and incidence rate of adverse reactions were compared. Results The total effective rate in study group was significantly higher than that in control group (P<0. 01). After treatment, serum and fecal IL-6 and TNF-α levels were significantly lower, while IFN-γ levels were significantly higher than those before treatment in the two groups (P<0. 05); in study group, serum and fecal IL-6 and TNF-α levels were significantly lower, while IFN-γ level was significantly higher than those in control group (P<0. 05). There was no significant difference in the total in-cidence rate of adverse reactions between two groups ( P >0. 05). Conclusion Saccharomyces Boulardii Sachets in treatment of children with rotaviral enteritis may achieve good clinical effect and safety, and it can reduce IL-6 and TNF-α levels and improve IFN-γ level.关键词
布拉酵母菌散/轮状病毒肠炎/白介素-6/肿瘤坏死因子-α/干扰素-γKey words
Saccharomyces Boulardii Sachets/Rotaviral enteritis/Interleukin-6/Tumor necrosis factor-α/In-terferon-γ分类
医药卫生引用本文复制引用
朱志萍,王朝阳,陈建群,万晓龙..布拉酵母菌散对轮状病毒肠炎患儿血清和粪便IL-6、TNF-α及IFN-γ的影响[J].解放军医药杂志,2018,30(6):68-71,4.基金项目
江苏省卫生厅医改试点单位基金资助项目(YG201318) （YG201318）
