解放军医药杂志2018，Vol.30Issue(6)：100-104,5.DOI:10.3969/j.issn.2095-140X.2018.06.026
不同剂量羟考酮对老年腹腔镜胆囊切除患者术后应激反应、炎性因子及认知功能的影响
Effects of Different Doses of Oxycodone on Stress Reaction, Inflammatory Factors and Cognitive Function of Elderly Patients after Laparoscopic Cholecystectomy
摘要
Abstract
Objective To investigate effects of different doses of Oxycodone on stress reaction, inflammatory fac-tors and cognitive function of elderly patients after laparoscopic cholecystectomy. Methods A total of 200 elderly pa-tients undergoing laparoscopic cholecystectomy admitted during August 2016 and August 2017 were divided into group A (n=62), group B (n=70) and group C (n=68) according to drug doses. All patients were given Oxycodone by intra-venous injection before the surgery with a dose of 0. 10 mg/kg in group A, 0. 15 mg/kg in group B and 0. 20 mg/kg in group C. Changes of stress reaction, inflammatory factors and cognitive function were compared before anesthesia, at 4 h, 12 h and 24 h after operation among three groups. Results At 4 h, 12 h and 24 h after operation, levels of serum corti-sol and epinephrine in group B were significantly lower than those in group A and C, and the levels in group C were sig-nificantly lower than those in group A (P<0. 05). At 4 h, 12 h and 24 h after operation, in group B and C, levels of se-rum interleukin -6 were significantly lower than that in group A, and score of mental state scale was significantly higher than that in group A (P<0. 05). At 12 h and 24 h after operation, levels of serum tumor necrosis factor-α in group B and C were significantly lower than those in group A ( P<0. 05). Incidence rates of adverse reactions in group A and group B were significantly lower than that in group C (P<0. 05), but there was no significant difference in incidence rate of adverse reactions between group A and B (P>0. 05). Conclusion Preoperative intravenous injection of 0. 15 mg/kg Oxycodone for elderly patients undergoing laparoscopic cholecystectomy is helpful for recovery of cognitive function, and it may obviously inhibit postoperative stress response and maintain the balance of proinflammatory and anti-inflammatory cytokines with good safety.关键词
胆囊切除术,腹腔镜/羟考酮/应激/炎性因子/认知Key words
Cholecystectomy, laparoscopic/Oxycodone/Stress/Inflammatory factors/Cognition分类
医药卫生引用本文复制引用
刘旭江,许舒娅,朱亚妮..不同剂量羟考酮对老年腹腔镜胆囊切除患者术后应激反应、炎性因子及认知功能的影响[J].解放军医药杂志,2018,30(6):100-104,5.基金项目
湖北省自然科学基金(6CFB506) （6CFB506）
