解放军医药杂志2018，Vol.30Issue(6)：109-112,4.DOI:10.3969/j.issn.2095-140X.2018.06.028
丙泊酚和七氟烷麻醉对老年胸外科手术患者术后认知功能的影响
Effect of Propofol and Sevoflurane Anesthesia on Postoperative Cognitive Function in Elderly Patients with Tho-racic Surgical Procedures
摘要
Abstract
Objective To analyze effect of Propofol and Sevoflurane anesthesia on postoperative cognitive func-tion in elderly patients with thoracic surgical procedures. Methods A total of 120 elderly patients undergoing thoracic surgical procedures during June 2015 and December 2016 were divided into observation group and control group (n=60 for each group) according to different anaesthetic methods. Observation group was injected with Propofol intravenously for anesthesia, while control group was given Sevoflurane inhalation for anesthesia. Operative related indexes, mini mental state examination scale (MMSE) score and serum S100β levels at different time points were compared in two groups. Re-sults Recovery of spontaneous breathing time, eye opening time and extubation time in observation group were signifi-cantly shorter than those in control group (P<0. 01). MMSE scores in postoperative 1sth, 3thh and 6thh were signifi-cantly lower than those in preoperative 1sth in two groups, and the scores in observation group were higher than those in control group (P<0. 05). Serum S100β levels in postoperative 1sth, 6thh, 12thh, 48thh and 72thh were significantly higher than those in preoperative 1sth in two groups, and the levels in observation group were lower than those in control group (P<0. 05). Incidence rate of adverse reactions in observation group was significantly lower than that in control group (P<0. 05). Conclusion Propofol anesthesia may achieve less lesions of cognitive function and less degree of in-creased serum S100β level in elderly patients undergoing thoracic surgical procedures, and therefore clinicians should choose anaesthetic methods appropriately according to patient's condition so as to reduce incidence rate of postoperative cognitive dysfunction.关键词
丙泊酚/七氟烷/老年人/胸外科手术/认知障碍Key words
Propofol/Sevoflurane/Aged/Thoracic surgical procedures/Cognition disorders分类
医药卫生引用本文复制引用
刘爱华,尹芳,田利川,王月新..丙泊酚和七氟烷麻醉对老年胸外科手术患者术后认知功能的影响[J].解放军医药杂志,2018,30(6):109-112,4.基金项目
沧州市科技支撑计划项目(151302062) （151302062）
