河北医学2018，Vol.24Issue(6)：890-894,5.DOI:10.3969/j.issn.1006-6233.2018.06.003
多药耐药相关蛋白1在骨肉瘤中的表达及同患者病理特征关系的分析
Expression of Multidrug Resistance Associated Protein 1 in Osteosarcoma and the Relationship with Pathological Characteristics
摘要
Abstract
Objective: To investigate the expression of multidrug resistance associated protein 1 ( MRP1) in osteosarcoma and its relationship with pathological features of osteosarcoma. Methods: 80 cases of osteosarcoma admitted to our hospital from January 2016 to January 2017 were selected as the research group. Meanwhile, 20 healthy persons in the same period were selected as control group. The difference between MRP1 in the two groups was compared, and the relationship between MRP1 and tumor stage and tumor size was analyzed. Results: The positive rate and positive rate of MDR1 in osteosarcoma patients were significantly higher than those in normal bone tissue (P＜0.05). The positive expression of MDR1 and P-gP in grade Ⅲ patients and grade Ⅳ patients were significantly higher than those in grade Ⅰ and grade Ⅱ patients ( P ＜0.05) . The positive rate of MDR1 and P-gP expression in large tumor patients and the positive rate were significantly lower than those in patients with small tumors ( P ＜0.05) . Conclusion: The expression of MDR1 is positively related to the pathological grade of osteosarcoma patients, and there is a negative correlation with the size of the tumor. It is necessary for the medical staff to pay attention to the clinical treatment.关键词
多药耐药相关蛋白1/骨肉瘤/病理特征Key words
Multidrug resistance associated protein 1/Osteosarcoma/Pathological features引用本文复制引用
李战鹏..多药耐药相关蛋白1在骨肉瘤中的表达及同患者病理特征关系的分析[J].河北医学,2018,24(6):890-894,5.基金项目
河北省科技计划项目,(编号:1711042H) （编号:1711042H）
