河北医学2018，Vol.24Issue(6)：898-902,5.DOI:10.3969/j.issn.1006-6233.2018.06.005
卷曲霉素联合莫西沙星胸腔注射对结核性胸膜炎患者血清和胸腔积液IFN-γ TNF-α CEA ADA水平的影响
Effects of Crimomycin Combined with Moxifloxacin Intrathoracic Injection on the Serum and Pleural Effusion Interferon-γ TNF-α CEA and ADA Levels of Patients with Tuberculous Pleurisy
摘要
Abstract
Objective: To research the effect of crimomycin combined moxifloxacin intrathoracic injec-tion on the serum and pleural effusion interferon-γ( IFN-γ) , tumor necrosis factor-α( TNF-α) , carcinoem-bryonic antigen ( CEA) , adenosine deaminase ( ADA) levels of patients with tuberculous pleurisy. Methods:98 cases of patients with tuberculous pleurisy admitted to our hospital from April 2013 to April 2016 were se-lected and randomly divided into two groups, the control group was treated with crimomycin, while the experi-mental group was treated with moxifloxacin based on the control group. The clinical curative effect, changes of serum and pleural effusion IFN-γ, TNF-α, CEA, ADA, forced vital capacity ( FVC) , forced expiratory vol-ume in 1 second ( FEV1) , pleural thickness levels before and after treatment and incidence of adverse reac-tions were compared between two groups. Results: The total effective rate of experimental group was higher than that of the control group (P＜0.05). Serum and pleural effusion IFN-γ, FVC and FEV1 in two groups were significantly higher than those before treatment, and the above indexes were significantly higher in the ex-perimental group than in the control group. Serum TNF- α, CEA, ADA and pleural thickness in two groups were significantly lower than before treatment, and the above indexes were significantly lower than those in the control group. There were statistically significant differences in the interactions between the two groups, be-tween different time points, between groups, and between different time points ( P＜0.05) . There was no sta- tistically significant difference between the two groups ( P＞0. 05) . Conclusion: The curative effect of crimo-mycin combined moxifloxacin intrathoracic injection was bettetr than monocolomycin alone with tuberculous pleurisy patients in the treatment of patients with tuberculous pleurisy, whcih can effectively regulate the serum and pleural effusion levels of interferon-γ, TNF-α, CEA, ADA.关键词
结核性胸膜炎/卷曲霉素/莫西沙星Key words
Tuberculous pleurisy/Crimomycin/Moxifloxacin引用本文复制引用
陶冠宇,杨仁旭,任焱,熊浪,刘南伶..卷曲霉素联合莫西沙星胸腔注射对结核性胸膜炎患者血清和胸腔积液IFN-γ TNF-α CEA ADA水平的影响[J].河北医学,2018,24(6):898-902,5.基金项目
四川省科技攻关项目,(编号:20120153) （编号:20120153）
