河北医学2018，Vol.24Issue(6)：914-918,5.DOI:10.3969/j.issn.1006-6233.2018.06.009
来氟米特联合中等剂量泼尼松治疗IgA肾病的临床疗效及对血清ICAM-1 MCP-1 TGF-β1的影响
Clinical Efficacy of Leflunomide Combined with Moderate Dose Prednisone in Treatment of IgA Nephropathy and Effects on Serum Levels of ICAM-1 MCP-1 and TGF-β1
摘要
Abstract
Objective: To investigate the effect of leflunomide combined with moderate doses of predni-sone in the treatment of IgA nephropathy ( Immunoglobulin A nephropathy) the clinical effect of serum inter-cellular adhesion molecule -1 ( ICAM-1 intercellular adhesion molecule-1) , monocyte chemoattractant pro-tein -1 ( monocyte chemotactic protein 1, MCP-1) , transformation growth factor beta 1 ( transforming growth factor beta TGF- 1, β1) . Methods: 96 patients with IgA nephropathy admitted to our hospital from October 2013 to May 2016 were randomly divided into control group and experimental group, with 48 cases in each group. All patients on admission were treated with conventional treatment. On the basis of this treatment, the control group received a large dose of prednisone, and the experimental group received leflunomide and a me-dium dose of prednisone. The clinical efficacy of the two groups before and after treatment was observed and compared. The levels of serum ICAM-1, MCP-1, TGF-β1, adverse reactions were observed in the two groups. Results: After treatment, the effective rate of the experimental group (95.83%) was higher than that of the control group (81.25%), and the difference was statistically significant (P＜0.05). 3 months and 6 months after treatment, the levels of serum ICAM-1, MCP-1 and TGF-β1were significantly decreased in the two groups, and the experimental group was significantly lower than that of the control group. There was a sig-nificant difference in the interaction between the two groups, different points and between groups and at the same time ( P＜0.05) . There was no significant difference in adverse reactions between the two groups ( P＞0. 05) . Conclusion: The effect of leflunomide and moderate dosage of prednisone in the treatment of IgA ne-phropathy is sure to reduce the level of serum ICAM-1, MCP-1 and TGF-β1, which is worthy of clinical ap-plication.关键词
IgA肾病/来氟米特/中等剂量泼尼松Key words
IgA nephropathy/Leflunomide/Medium dose prednisone引用本文复制引用
赵敬安,纪燕..来氟米特联合中等剂量泼尼松治疗IgA肾病的临床疗效及对血清ICAM-1 MCP-1 TGF-β1的影响[J].河北医学,2018,24(6):914-918,5.基金项目
湖北省自然科学基金项目,(编号:2012FFA016) （编号:2012FFA016）
