河北医学2018，Vol.24Issue(6)：1004-1007,4.DOI:10.3969/j.issn.1006-6233.2018.06.033
CT灌注成像对急性缺血性脑卒中静脉溶栓治疗的安全性和有效性评价
Evaluation of Safety and Efficacy of CT Perfusion Imaging in Intravenous Thrombolytic Therapy for Acute Ischemic Stroke
摘要
Abstract
Objective: To explore the guiding role of CT perfusion imaging in the safety and efficacy of intravenous thrombolytic therapy for acute ischemic stroke. Methods: 75 patients with acute middle cerebral artery ischemic stroke (6h) admitted in our hospital from October 2016 to December 2017 were selected as the subjects. The CBF ratio of 35 cases underwent CTP examination ranged from 0.20 to 0.35, suggesting reversi-ble ischemia penumbra. The remaining 40 cases were examined by CTP without ischemic penumbra. The two groups were treated with rt-PA thrombolytic therapy. The bleeding conversion rate, mortality rate, NIHSS score and Barthel index score of 24h, 7d, 30d and 90d after thrombolysis in two groups were compared. Re-sults: There were 1 case of hemorrhage conversion within 48 hours after thrombolytic therapy in IP group and 4 cases of hemorrhage conversion within 48 hours after thrombolytic therapy in no IP group,there were signifi-cant differences (P＜0.05).There were no deaths in IP group after thrombolytic therapy, and there were 1 deaths in 14d after thrombolytic therapy in group IP, no significant difference (P＝0.095).NIHSS scores and Barthel index scores after 24h, 7d, 30d and 90d after treatment in CTP group were better to control group and the difference was statistically significant ( P＜0.05) . Conclusion: In the thrombolytic therapy of patients with acute ischemic stroke, according to the results of CTP examination, it is important to predict the risk of sec-ondary hemorrhage after thrombolytic therapy, which is of great significance to the improvement and prognosis of neural function defects.关键词
CT灌注成像/急性缺血性脑卒中/缺血半暗带/出血转化/rt-PA溶栓Key words
CT perfusion imaging/Acute ischemic stroke/Ischemic penumbra/Hemorrhagic transformation/rt-PA thrombolysis引用本文复制引用
李卫来,李琳,李岩,郭晓玲..CT灌注成像对急性缺血性脑卒中静脉溶栓治疗的安全性和有效性评价[J].河北医学,2018,24(6):1004-1007,4.基金项目
河北省承德巿科技计划项目,(编号:20151083) （编号:20151083）
