河北医学2018，Vol.24Issue(6)：1028-1032,5.DOI:10.3969/j.issn.1006-6233.2018.06.039
中晚期PHC患者TACE术前后血清Th1/Th2细胞因子AFP水平的变化及意义
Change and Significance of Levels of Serum Th1/Th2 Cytokines and AFP before and after TACE in Advanced PHC Patients
摘要
Abstract
Objective: To explore the levels changes of serum Th1/Th2 cytokines and AFP in patients with advanced hepatocellular carcinoma ( PHC) before and after transcatheter arterial chemoembolization ( TA-CE) and their clinical significance. Methods: 95 cases of PHC patients hospitalized in our hospital were di-vided into the TACE group ( n＝58, given TACE treatment) and the venous group ( n＝37, given intravenous chemotherapy) . The lesion reduction degree and the levels of serum Th1/Th2 cytokines and AFP before and after TACE were compared between the two groups. Results: The total reduction rate of lesion in the TACE group was significantly higher than that in the venous group ( P＜0.05) . The serum AFP level, the AFP posi-tive rate and the levels of serum interleukin-4 ( IL-4) and interleukin-10 ( IL-10) were significantly de-creased after treatment in the two groups ( P＜0.05) while the levels of interferon-γ ( IFN-γ) and interleukin-2 ( IL-2) were significantly increased ( P＜0.05) . The levels changes of serum AFP and Th1/Th2 cytokines in the TACE group were higher than those in the venous group ( P＜0.05) . The positive expression rate of IL-10 in the TACE group was significantly lower than that in the venous group ( P＜0.05) . Conclusions: TACE treatment can effectively control the disease condition of advanced PHC and regulate Th1/Th2 balance disor-ders, and the levels of serum Th1/Th2 cytokines and AFP can be used as important indicators for efficacy e-valuation.关键词
原发性肝癌/TACE/Th1/Th2细胞因子/甲胎蛋白Key words
Primary hepatocellular carcinoma/TACE/Th1/Th2 cytokines/Alpha fetoprotein引用本文复制引用
王碧玉,王露莹,羊文芳..中晚期PHC患者TACE术前后血清Th1/Th2细胞因子AFP水平的变化及意义[J].河北医学,2018,24(6):1028-1032,5.基金项目
海南省卫生计生行业科研项目,(编号:20161763) （编号:20161763）
