煤炭与化工2018，Vol.41Issue(4)：131-133,3.DOI:10.19286/j.cnki.cci.2018.04.039
4-(4-吡啶)-2-巯基-1,3噻唑的制备工艺优化
Optimization on preparation technology of 4-(4-pyridine)-2-mercapto-1,3 Thiazole
温宁 1冯晓颖2
作者信息
- 1. 河北亚诺生物科技股份有限公司,河北 石家庄 052160
- 2. 河北常山生化药业股份有限公司,河北 石家庄 050021
- 折叠
摘要
Abstract
4-(4-Pyridine)-2-mercapto-1, 3 thiazole(PTT)is a intermediate of cephalosporin derivaties TAK-599, which synthetic process is first 2 — bromo-1-(4-pyridinyl)-1-ethanone hydrobromide(BAP)is prepared from 4-acetyl pyridine and hydrogen bromide solution, then ADTC is obtained through adding carbon disulfide and ethyl acetate to BAP. Finally the product PTT was obtained through the neutralization reaction by sodium acetate. The synthetic process was optimized. PTT is prepared by the potimizing process, the product content is more than 99％, ADTC yield reaches 82％, PTT total yield reaches 66％.关键词
4-(4-吡啶)-2-巯基-1,3噻唑(PTT)/4-乙酰基吡啶/合成/稳定性Key words
4-(4-pyridine)-2-mercapto-1, 3 thiazole(PTT)/4-acetyl pyridine/synthesis/stability分类
化学化工引用本文复制引用
温宁,冯晓颖..4-(4-吡啶)-2-巯基-1,3噻唑的制备工艺优化[J].煤炭与化工,2018,41(4):131-133,3.
