湖南大学学报（自然科学版）2018，Vol.45Issue(6)：133-138,6.DOI:10.16339／j.cnki.hdxbzkb.2018.06.020
Lewis酸催化三组分合成喹啉-2,4-二羧酸酯类化合物*
Synthesis of Quinoline-2,4-dicarboxylate Compounds Based on Three-Component Coupling Catalyzed by Lewis Acid
摘要
Abstract
An efficient method for synthesizing quinoline-2,4-dicarboxylate compounds was developed via a one-pot reaction of catalyzed lewis acid such as cheap and easily obtained AlCl3,CuCl2 and FeCl3 in-stead of aromatic amines,ethyl glyoxylate and methyl pyruvate.The major products were separated and purified by thin-layer chromatography,and their structures were characterized by FT-IR,1H NMR,13C NMR and elemental analysis.The reaction mechanism and the influence of substituents attached to aro-matic amine for the reaction were discussed,which will provide a useful reference for molecular design and synthesis of this kind of novel compounds in the future.This method has some advantages such as cheap materials,mild reaction conditions,high atom economy and high yield.[12]GANDEEPAN P,RAJAMALLI P.Synthesis of substituted quinolines by iron(Ⅲ)-catalyzed three-component coupling re-action of aldehydes,amines,and styrenes[J].Asian Journal of Organic Chemistry,2014,3(3):303-308.关键词
芳胺/乙醛酸乙酯/丙酮酸甲酯/Lewis酸/喹啉衍生物Key words
aromatic amine substitution/ethyl glyoxylate/methyl pyruvate/Lewis acid/quinoline de-rivatives分类
化学化工引用本文复制引用
程正载,Mario Gauthier,王云,谢聪,唐然,王涵鼎,丁玲,刘锋波,颜晓潮,朱三勇..Lewis酸催化三组分合成喹啉-2,4-二羧酸酯类化合物*[J].湖南大学学报（自然科学版）,2018,45(6):133-138,6.基金项目
湖北省自然科学基金资助项目(2017CFB680),National Natural Science Foundation of Hubei Province(2017CFB680) （2017CFB680）
湖北省教育厅中青年人才项目(Q20162806) （Q20162806）
煤转化与新型炭材料湖北省重点实验室开放基金资助项目(WKDM201509) （WKDM201509）
国家大学生科学基金资助项目(201510488004). （201510488004）
