湖南中医药大学学报2018，Vol.38Issue(3)：261-265,5.DOI:10.3969/j.issn.1674-070X.2018.03.008
整合素αvβ3介导EPCs修复损伤血管内皮及补阳还五汤的干预作用
Intervention Effect of Buyang Huanwu Decoction on Integrin αvβ3-Mediated EPCs in Repairing Damaged Vascular Endothelium
摘要
Abstract
Objective To investigate the role of Buyang Huanwu decoction (BYHWD) in promoting endothelial progenitor cell (EPC)-induced recovery of injuried endothelial cells, and explain the mechanism from EPCs homing. Methods The endothelial injuried rats were given gavage with BYHWD and vena caudalis injection of EPC. The repaired situation of injuried endothelium was observed. The effect of BYHWD on EPC homing was analyzed from integrin αvβ3 and integrin αvβ5-mediated SDF-1/CXCR-4 signaling pathway. Results Compared with group EPC (group E) and BYHED group (group b), the protein expression of vascular αvβ3 in BYHWD combined with EPC (group B) increased more significantly (P<0.05), vascular SDF-1 expression increased significantly (P<0.0l). Conclusion BYHED could promote EPC repairing damaged endothelium, the mechanism may be related to promote EPCs homing through upregulating αvβ3-mediated SDF-1signaling pathway.关键词
整合素αvβ3/整合素αVβ5/内皮祖细胞/补阳还五汤/归巢Key words
integrin αvβ3/integrin αvβ5/Endothelial progenitor cell/Buyang Huanwu decoction/homing分类
医药卫生引用本文复制引用
贺冰,刘晓丹,李亮,李平,张伟..整合素αvβ3介导EPCs修复损伤血管内皮及补阳还五汤的干预作用[J].湖南中医药大学学报,2018,38(3):261-265,5.基金项目
国家自然科学基金资助项目(81001494) （81001494）
湖南省教育厅重点实验室开放基金项目(15k059) （15k059）
湖南省自然科学基金项目(2016JJ4069). （2016JJ4069）
