摘要
Abstract
Objective:To observe the result of analysis on brain CT of 80 cases of patients with treatmentresistant schizophrenia, understand the relationship between the changes of brain and the onset of schizophrenia, and investigate its clinical features. Methods: A total of 80 cases of patients with treatment-resistant schizophrenia took brain CT scan in our hospital from December 2012 to December 2015. Comparing them with the results of brain CT on 80 cases of normal and grouping all the participants into the observation group and the control group respectively. Investigating the symptoms of schizophrenia of patients by Minnesota Multiphasic Personality Inventory (MMPI). The relationship between family history, sex, character and age of patients with brain atrophy was studied by CT test. Results: 45 cases of patients out of 80 cases of patients with treatment-resistant schizophrenia showed diffuse brain atrophy, including 19 cases of cortical type, 8 cases of medullary type, 15 cases of cortical and medullary type, 2 cases of cerebellar atrophy type and one case of increased nucleus density on both sides;The control group only had 2 cases of brain atrophy, the difference between the two groups was statistically significant(x2 =55. 7033, P＜0. 001). The MMPI scores of patients all exceeded 50 at the aspect of social introversion, athopia, split personality, hypomania, bigotry, hysteria, depression, hypochondriasis and their mental symptoms were serious. Meanwhile, 27 cases of 40-49 patients in the observation group accounted 60％, there were significant differences in different age groups(X2 =16. 533, P＜0. 0l). There was no significant difference between male and female patients with cerebral atrophy(P＞0. 05). There was no significant difference in the family history of schizophrenia or no. Conclusion:It is found with the brain CT scan of the patients with treatment-resistant schizophrenia that more than half of the patients show different types of brain atrophy and brain atrophy is closely related to treatment-resistant schizophrenia.关键词
难治性精神分裂症/脑部CT/临床特征/明尼苏达多相人格量表Key words
Treatment-resistant schizophrenia/Brain CT/Clinical feature/MMPI分类
医药卫生
