解放军医学院学报2018，Vol.39Issue(1)：24-27,4.DOI:10.3969/j.issn.2095-5227.2018.01.007
血清人附睾蛋白4与CA125在上皮性卵巢癌中的表达及其与预后的关系
Expressions of serum human epididymis protein 4 and CA125 in patients with epithelial ovarian cancer and their relationships with prognosis
唐梅 1林丽慧 1林元 1薛万兴 1苏红娥1
作者信息
- 1. 海南西部中心医院 妇产科, 海南那大 571799
- 折叠
摘要
Abstract
Objective To investigate the expressions of serum human epididymis protein 4 (HE4) and carbohydrate antigen 125(CA125) in epithelial ovarian cancer (EOC), and analyze their relationships with prognosis. Methods One hundred and thirty-eight patients with EOC (EOC group), 106 patients with benign epithelial ovarian tumors (benign group) and 106 healthy women (control group) selected from January 2011 to December 2014 in the Central Hospital of Western Hainan were included in this study. The serum levels of HE4 and CA125 were detected by chemiluminescence method. Kaplan-Meier curve and COX regression analysis were performed to explore prognostic factors of EOC. Results The levels of serum HE4 and CA125 in EOC group were significantly higher than those in benign group and control group [HE4 (pmol/L): (309.42 ± 56.83) vs (57.26±15.48) and (51.30± 11.36); CA125 (U/ml): (80.37±30.65) vs (26.43土11.48) and (21.75 ± 9.62), all P ＜ 0.01]. Cox regression analysis showed that clinical stage [HR (95％ CI): 1.842 (1.395-2.641)], lymph node metastasis [HR (95％ CI): 3.714 (2.875-5.129)], tumor recurrence [HR (95％ CI):4.315 (3.162-6.248)], HE4 [HR (95％ CI): 1.936 (1.416-2.758)] and CA125 [HR (95％ CI): 1.527 (1.124-2.260)] expression were independent prognostic factors for EOC (All P ＜ 0.01). Conclusion HE4 and CA125 levels increase significantly in EOC, which are the risk factors for poor prognosis.关键词
上皮性卵巢癌/人附睾蛋白4/糖类抗原125/预后Key words
epithelial ovarian cancer/human epididymal protein 4/carbohydrate antigen 125/prognosis分类
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唐梅,林丽慧,林元,薛万兴,苏红娥..血清人附睾蛋白4与CA125在上皮性卵巢癌中的表达及其与预后的关系[J].解放军医学院学报,2018,39(1):24-27,4.
