解放军医学院学报2018，Vol.39Issue(1)：62-64,74,4.DOI:10.3969/j.issn.2095-5227.2018.01.017
海水浸泡小型猪模型的建立及血流动力学与动脉血气指标的检测与分析
Establishment of miniature pig model of seawater immersion and its hemodynamic and arterial blood gas index analysis
摘要
Abstract
Objective The miniature pig was used to establish the animal model of seawater immersion wound for further study of physiological and pathological changes in seawater immersion wound. Methods Ten 4-month Bama pigs and another 10 4-month Guizhou Ⅲ miniature pigs were soaked into seawater for 3 hours to simulate seawater immersion. Then hemodynamic and arterial blood gas parameters changes were recorded and compared between different time points and different genders. Results The heart rate (HR) and mean arterial pressure (MAP) of both Guizhou and Bama miniature pigs increased significantly [HR: (100.80±8.73)/min vs (107.61±7.81)/min, P=0.033 in Guizhou group; (103.74±7.51)/min vs (111.45±4.90)/min, P=0.021 in Bama group; MAP: (108.80土12.97) mmHg vs (120.52±9.66) mmHg (1 mmHg=0.133 kPa), P=0.039 in Guizhou group; (94.76 ± 11.25) mmHg vs(104.91 ± 11.32) mmHg, P=0.018 in Bama group], while the 02 partial pressure (P02) decreased significantly [(93.45±8.26) mmHg vs(90.07±6.83) mmHg, P=0.041 in Guizhou group; (94.23±5.77) mmHg vs (91.34±7.18) mmHg, P=0.037 in Bama group]. After soaking in the seawater, the HR, MAP and P02 of female miniature pig were significantly higher than those of male miniature pigs[HR: (117.90±7.69/min vs (93.45 ± 6.71)/min, P=0.025 in Guizhou group; (124.5±4.93)/min vs (97.63 ± 5.70)/min, P=0.018 in Bama group; MAP: (121.50±15.66 mmHg vs (96.83±10.96) mmHg, P=0.011 in Guizhou group, (117.65±13.34) mmHg vs(83.51±10.25) mmHg, P=0.017 in Bama group; PO2: (92.97±7.83) mmHg vs (89.47±8.19) mmHg, P=0.036 in Guizhou group;(93.34±7.88) mmHg vs (90.23±6.77) mmHg, P=0.031 in Bama group]. Conclusion We have established miniature pig model of seawater immersion wound, and got some hemodynamic and arterial blood gas indexes, which may provide basis for further medical biology research.关键词
海水浸泡伤/病理生理学/小型猪/动物模型Key words
seawater immersion wound/pathophysiology/miniature pig/animal models分类
医药卫生引用本文复制引用
陈志达,郗洪庆,乔治,唐云..海水浸泡小型猪模型的建立及血流动力学与动脉血气指标的检测与分析[J].解放军医学院学报,2018,39(1):62-64,74,4.基金项目
海南省社会发展科技专项项目(2015SF22) Supported by Science and Technology Special for Social Development of Hainan Province(2015SF22) （2015SF22）
