解放军医学院学报2018，Vol.39Issue(2)：102-105,109,5.DOI:10.3969/j.issn.2095-5227.2018.02.004
血清尿酸水平与冠心病患者远期预后的分析
Relationship between serum uric acid level and long-term prognosis in patients with coronary heart disease
徐萃 1刘宏斌 2王娟 1肖湖南3
作者信息
- 1. 解放军总医院 南楼心血管内科, 北京 100853
- 2. 解放军第305医院, 医务部, 北京 100017
- 3. 首都医科大学附属北京朝阳医院 心血管内科, 北京 100020
- 折叠
摘要
Abstract
Objective To investigate the relationship between serum uric acid level and long-term prognosis in patients with coronary heart disease. Methods From January 2011 to September 2014, clinical data about 3 679 patients of coronary heart disease with an average age of (61.46±11.66) years in Chinese PLA General Hospital were retrospectively analyzed, and their blood pressure, heart rate, weight, height and blood biochemical tests results were recorded. The primary endpoint was defined as cardiovascular disease related death and the average follow-up period was (39.0 ± 11.0) months. Patients were divided into four groups by uric acid levels, and then the relationship between serum uric acid level and long-term prognosis was analyzed. Results Multivariate cox-regression analysis showed that serum uric acid (HR=1.035; 95％ CI: 1.018-1.052; P=0.038) and age (HR=1.070; 95％ CI: 1.055-1.085; P ＜ 0.001) were independent risk factors for cardiovascular disease related death in patients with coronary heart disease. While, statins (HR=0.419; 95％ CI: 0.272-0.644; P ＜ 0.001) and HDL-C(HR=0.321; 95％ CI: 0.182-0.565; P ＜ 0.001) were protective factors. Kaplan-Meier analysis showed that with the increase of serum uric acid level, the cumulative survival rate decreased significantly. There might be a threshold effect between uric acid and mortality in patients with coronary heart disease. Conclusion Uric acid is an independent risk factor for cardiovascular disease related death in patients with coronary heart disease. Thus, control of hyperuricemia is expected to reduce mortality in patients with coronary heart disease.关键词
尿酸/冠心病/死亡率Key words
uric acid/coronary heart disease/mortality分类
医药卫生引用本文复制引用
徐萃,刘宏斌,王娟,肖湖南..血清尿酸水平与冠心病患者远期预后的分析[J].解放军医学院学报,2018,39(2):102-105,109,5.
