摘要
Abstract
Objective To evaluate the optimum dose of oxycodone for prevention of catheter related bladder discomfort (CRBD) during recovery period from general anesthesia with radical thyroidectomy. Methods One hundred and fifty male patients who underwent radical thyroidectomy in the First Center Hospital of Baoding from December 2015 to May 2017 were included in this study. All the patients were classified as ASA physical status I - Ⅱ, and randomly divided into five groups with 30 in each group: control group (group C), oxycodone 0.03 mg/kg group (group O1), oxycodone 0.06 mg/kg group (group O2), oxycodone 0.09 mg/kg group (group 03) and oxycodone 0.12 mg/kg group (group 04). At 15 minutes before the end of surgery, oxycodone was intravenously injected at dosage of 0.03 mg/kg, 0.06 mg/kg, 0.09 mg/kg, 0.12 mg/kg in group O1, group O2, group 03 and group 04, respectively. And 15 ml 0.9％ NaCl solution was intravenously injected in group C. The occurrence and severity of CRBD at 4 h after surgery, and the occurrence of dizziness, respiratory depression and nausea and vomiting were observed and recorded. Results Severity of CRBD decreased accordingly in group C, group O1, group O2, group O3 and group O4, and significant differences were found between each two groups (P ＜ 0.05) except group o1 vs group O2, and group O3 vs group O4. Compared with group 04, the incidences of dizziness, respiratory depression and nausea and vomiting were significantly lower in group C, group O1, group 02 and group 03 (P ＜ 0.05). Conclusion The optimum dose of oxycodone for prevention of CRBD during recovery from general anesthesia is 0.09 mg/kg.关键词
羟考酮/导尿管相关膀胱刺激征/麻醉恢复期Key words
oxycodone/catheter related bladder discomfort/anesthesia recovery period分类
医药卫生
