解放军医学院学报2018，Vol.39Issue(3)：181-184,4.DOI:10.3969/j.issn.2095-5227.2018.03.001
前哨淋巴结活检阳性乳腺癌患者避免腋窝淋巴结清扫的探讨
Predictive factors of avoiding axillary lymph node dissection in breast cancer patients with positive result of sentinel lymph node
摘要
Abstract
Objective To investigate the predictive factors of further axillary lymph node dissection in patients with sentinel lymph node biopsy (SLNB)-positive breast cancer. Methods Clinical data about patients with breast cancer received SLNB in Chinese PLA General Hospital from January 2007 to November 2016 were retrospectively collected to investigate the predictive factors of avoiding further axillary lymph node dissection in SLNB-positive breast cancer patients. Results Of the 196 SLNB-positive patients, 121 (61.7％) patients had negative axillary lymph nodes' results and 75 had positive. In univariate analysis, there were significantly statistical differences between two categories in age (P=0.062), histological grade (P=0.009), number of positive sentinel lymph nodes (P=0.002) and pathological T staging (P=0.078). Multivariate analysis revealed that the number of positive sentinel lymph nodes (≥3 vs 1, OR=4.159, P=0.003) and histological grade of breast cancer (Ⅲ vs Ⅰ, OR=2.287, P=0.011) provided further indications for ALND. Conclusion Patients with one positive SLN or SBR grade I are recommended to be exempt from ALND and receive adjuvant therapy after surgery.关键词
乳腺癌/前哨淋巴结活检/腋窝淋巴结清扫Key words
breast carcinoma/sentinel lymph node biopsy/axillary lymph node dissection分类
医药卫生引用本文复制引用
朱军永,原晓燕,朱芸生,王派,李捷,王全胜,刘梅,李席如..前哨淋巴结活检阳性乳腺癌患者避免腋窝淋巴结清扫的探讨[J].解放军医学院学报,2018,39(3):181-184,4.基金项目
国家自然科学基金面上项目(81372386) （81372386）
Supported by the National Natural Science Foundation of China (81372386) （81372386）
