解放军医学院学报2018，Vol.39Issue(3)：196-199,4.DOI:10.3969/j.issn.2095-5227.2018.03.005
轻型卒中患者行重组组织型纤溶酶原激活剂静脉溶栓治疗的疗效观察
Clinical efficacy of intravenous thrombolysis with recombinant tissue plasminogen activator on patients with minor ischemic stroke
石少亭 1王林 1柏玉兰 1李军朝 1张蓓1
作者信息
- 1. 西安医学院第一附属医院 神经内科, 陕西西安 710077
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy and safety of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) on patients with acute minor ischemic stroke (MIS). Methods One hundred and twelve patients who were diagnosed as MIS and admitted to our hospital within the time window of intravenous thrombolysis (4.5 h) from January 2015 to March 2017 were recruited in our study. These patients were then divided into three groups: intravenous thrombolysis within 0-3 h (n=14), intravenous thrombolysis within 3-4.5 h (n=32) and without intravenous thrombolysis (n=66). Patients in intravenous thrombolysis groups received the rt-PA therapy, and then were treated with dual anti-platelet therapy by aspirin and clopidogrel within 24 hours. Patients in without intravenous thrombolysis group received 300 mg clopidogrel therapy, and then were treated with dual anti-platelet therapy by aspirin and clopidogrel within 24 hours. All the patients had received NIHSS scoring at admission, and then received NIHSS and mRS scoring after 3 months as well. Results There was no statistical difference in the NIHSS score at admission, and in the NIHSS and mRS score at 3 months between three groups within 3 months, acute ischemic stroke recurred in 2 cases in intravenous thrombolysis group, and 12 cases in without intravenous thrombolysis group, with statistically significant difference. Conclusion The clinical efficacy of intravenous thrombolysis within 0-3 h and within 3-4.5 h has no difference. Compared with patients without receiving intravenous thrombolysis therapy, patients receiving intravenous thrombolysis therapy do not acquire better prognosis, but it may reduce the recurrence rate of ischemic stroke within 3 months.关键词
轻型卒中/静脉溶栓/NIHSS评分/缺血性卒中Key words
minor ischemic stroke/intravenous thrombolysis/NIHSS score/acute ischemic stroke分类
医药卫生引用本文复制引用
石少亭,王林,柏玉兰,李军朝,张蓓..轻型卒中患者行重组组织型纤溶酶原激活剂静脉溶栓治疗的疗效观察[J].解放军医学院学报,2018,39(3):196-199,4.
