检验医学与临床2018，Vol.15Issue(12)：1707-1710,1715,5.DOI:10.3969／j.issn.1672-9455.2018.12.004
母体缺氧诱导因子-1α水平及胎盘血流变化与胎儿生长受限的相关性
Correlation of maternal hypoxia inducible factor-1α level,placental blood flow and fetal growth restriction
摘要
Abstract
Objective To investigate the correlation between maternal hypoxia inducible factor-1α(HIF-1α)level and placental blood flow level and the occurrence and development of fetal grow th restriction(FGR).Methods A total of 60 cases of FGR treated from October 2014 to October 2017 in the hospital were taken as the study group,and 60 cases of normal pregnant women during the same period were taken as con-trol group.The levels of HIF-1α in the fetal umbilical vein blood of two groups of subjects at 20,24,28,32,36 weeks,pre labor and delivery were detected.The dynamic changes in the ratio of the pulsatile index(PI),the blood flow resistance index(RI),the peak systolic peak of the umbilical artery and the end end velocity of the umbilical artery(S/D)were monitored.The expression level of HIF-1α in maternal placenta after fetal birth was calculated,and the incidence of adverse pregnancy events was recorded.Results Serum HIF-1α levels of the study group were significantly higher than those in the control group at 20,24,28,32,36 weeks and before delivery,and the difference was statistically significant(P＜0.05);the HIF-1α expression level of the placen-tal tissue section of the study group was significantly higher than that of the control group,the HIF-1α level of fetal umbilical vein blood was significantly higher than that of the control group,and the difference was statis-tically significant(P＜0.05);the blood flow PI,RI and S/D of the two groups of pregnant women gradually decreased with the increase of gestational age,and the maternal placental arterial blood flow PI,RI and S/D were significantly higher than those in the control group at 20,24,28,32,36,and before delivery,and the difference was statistically significant(P＜0.05);HIF-1α level of venous blood,HIF-1α level of fetal umbilical vein,HIF-1α level of placental tissue in maternal body after delivery,PI,RI and S/D of placental blood flow were positively correlated with FGR(P＜0.05);the overall incidence of adverse events in pregnant women in the study group was significantly higher than that in the control group,and the difference was statistically sig-nificant(P＜0.05).Conclusion The increase of HIF-1α level and the increase of placental blood flow PI,RI and S/D in pregnant women can increase the incidence of pregnancy complications and adverse pregnancy e-vents.关键词
缺氧诱导因子-1α/胎盘血流/胎儿生长受限Key words
hypoxia inducible factor-1α/placental blood flow/hetal grow th restriction分类
医药卫生引用本文复制引用
蒋玲玲,陈丽平,鲁晓燕,刘颖蕾,单峰,曹杨,刘曼华..母体缺氧诱导因子-1α水平及胎盘血流变化与胎儿生长受限的相关性[J].检验医学与临床,2018,15(12):1707-1710,1715,5.基金项目
江苏省南通市卫生和计划生育委员会青年医学人才科研基金资助项目(WQ2016029). （WQ2016029）
