检验医学与临床2018，Vol.15Issue(12)：1720-1722,1726,4.DOI:10.3969／j.issn.1672-9455.2018.12.007
不同剂量舒芬太尼在小儿短小手术麻醉诱导中的效果比较
Comparison of different doses of sufentanil for anesthesia induction in pediatric with minor surgery
摘要
Abstract
Objective To compare the efficacy and safety of different doses of sufentanil for anesthesia in-duction in pediatric with minor surgery.Methods A total of 60 children who udnerwent caspediatric surgery from March to October 2016 in Guangyuan Third People′s Hospital,aged 2 to 7 years old,grade Ⅰ classified by American Association of Anesthesiologists,with predicted duration of surgery ＜1 h,were randomly divid-ed into three groups with 20 cases in each group by using a random number table method:sufentanil 0.2 μg/kg group(group A),0.3 μg/kg group(group B),0.4 μg/kg group(group C).After intravenous injection of sufentanil in 0.2,0.3,0.4 μg/kg in group A,B and C respectively,the anesthesia induction of intravenous in-jection of 0.1 mg/kg of cisatracurium and 1.5 mg/kg of propofol was performed.The No.1.5 or 2.0 Cookgas laryngeal mask was inserted with PCV model for mechanical ventilation.The the systolic pressure(SBP),di-astolic blood pressure(DBP),heart rate(HR)and saturation(SPO2)values of the three groups were recor-ded before anesthesia(T0),after induction of anesthesia(T1),during intubation(T2)and 3 min after intuba-tion(T3).The time of anesthesia,operation time,recovery time,extubation time and total amount of sevoflu-rane were recorded.The quality of awakening was evaluated.The degree of agitation was assessed using the children′s recovery scale(PAED).The incidence of cardiovascular adverse events and laryngeal spasm during anesthesia were recorded.Results Compared with group C,the extubation time and recovery time of group A and group B significantly shorter,and the difference was statistically significant(P＜ 0.05),and the SBP in T1,T2 and T3 of group A and group B significantly increased,and the difference was statistically significant(P＜0.05).Compared with T0,the SBP,DBP and HR significantly decreased in T1,T2 and T3 of the three groups,SPO2was significantly increased,and the difference was statistically significant(P＜0.05).Compared with group A,the amounts of sevoflurane of group B and group C significantly decreased(P＜ 0.05);com-pared with group B,the amount of sevoflurane of group C was significantly reduced and the difference was sta-tistically significant(P＜0.05).Awakening quality of group B was higher than that of group C(P＜0.05).Compared with group A,the PAED score and the incidence of agitation of group B and group C decreased,and the differences were statistically significant(P＜ 0.05).There were 2 cases of sinus bradycardia(10％)in group C,and 2 cases with laryngeal spasm(10％)in group A.Conclusion The analgesic effect of sufentanil is effective and less side effects for anesthesia induction in pediatric with minor surgery,and the recommended dose is 0.3 μg/kg.关键词
舒芬太尼/全身麻醉/心脏指数Key words
sufentanil/general anesthetics/cardiac index分类
医药卫生引用本文复制引用
付雄,赵泽宇,曾会明,乔自玺..不同剂量舒芬太尼在小儿短小手术麻醉诱导中的效果比较[J].检验医学与临床,2018,15(12):1720-1722,1726,4.基金项目
四川省卫生和计划生育委员会科研项目(130250). （130250）
