检验医学与临床2018，Vol.15Issue(12)：1733-1736,4.DOI:10.3969／j.issn.1672-9455.2018.12.011
两种药物单独和联合使用对急性脑梗死患者血小板抑制率及超敏C反应蛋白水平的影响
Effects of two drugs alone and combined on platelet inhibition rate and high sensitivity C reactive protein level in patients with acute cerebral infarction
摘要
Abstract
Objective To study the clinical therapeutic effect of aspirin and clopidogrel and their effect on the level of serum related inflammatory factors in patients with acute cerebral infarction,and to provide a ref-erence for the individualized treatment of antiplatelet drugs.Methods A total of 300 patients with acute cere-bral infarction admitted in Shandong Provincial Third Hospital from January 2015 to December 2016,were di-vided into aspirin group(n＝100),clopidogrel group(n＝100)and the combination group(n＝100).Before and two weeks after treatment,thromboela-stogram(TEG)was used to determine the platelet inhibition rate of arachidonic acid(AA)level and adenosine diphosphate(ADP)pathway.Immunoturbidimetry was used to determine the level of serum hypersensitivity C reactive protein(hs-CRP)in the three groups of patients.Platelet inhibition rate,hs-CRP level,neurological function score and recurrence rate of stroke were compared between the three groups.Results The platelet inhibition rate induced by AA and ADP pathway after treat-ment in three groups were higher than those before treatment,and the difference was statistically significant(P＜0.05).The difference of platelet inhibition rate induced by AA level and ADP pathway between the 3 groups was statistically significant(P＜0.05).The level of serum hs-CRP in the 3 groups after treatment was significantly lower than before the treatment,the difference was statistically significant(P＜0.05).The serum hs-CRP level in the combined group was significantly lower than those in the other two groups(P＜0.05).The combined group had better neurological function recovery and lower stroke recurrence rate.Conclusion Both aspirin and clopidogrel have antiplatelet effect,but the combined use of two drugs can effectively inhibit platelet aggregation from two ways.It can play a stronger antiplatelet function,reduce platelet aggregation ac-tivity,reduce vasculitis reaction,and reduce the risk of thrombus recurrence.关键词
血栓弹力图/花生四烯酸/二磷酸腺苷受体/血小板抑制率/急性脑梗死Key words
thromboela-stogram/arachidonic acid/adenosine diphosphate receptor/platelet inhibi-tion rate/acute cerebral infraction分类
医药卫生引用本文复制引用
芦璐,高阳,房淑欣..两种药物单独和联合使用对急性脑梗死患者血小板抑制率及超敏C反应蛋白水平的影响[J].检验医学与临床,2018,15(12):1733-1736,4.基金项目
山东省交通科技创新计划基金资助项目(2013B21). （2013B21）
