Abstract
Objective To investigate the relationship between serum homocysteine(Hcy)level and central arterial pressure,carotid femoral artery pulse conduction velocity(cfPWV),central artery enhancement index(AIx)and endothelial function index(RHI)in the patients with refractory hypertension(RH).Methods A total of 124 patients with RH admitted in the hospital from May 2013 to November 2016 were enrolled in this study.Serum Hcy and vascular function index were measured.With Hcy and cfPWV ＞ fPWV2 as boundary values,the relative indexes of the two groups were analyzed and compared.Results(1)There was no signifi-cant difference in sex,age,course of disease,complication,smoking history,history of drinking,and medication status in the two groups of patients with Hcy ≥10 μmol/L(P＞0.05),and cfPWV,RHI,systolic blood pres-sure(SBP),diastolic pressure(DBP),total cholesterol(TC),three acyl glycerol(TG)in the group of Hcy＞10 μmol/L.The level of low density lipoprotein cholesterol(LDL-C)was significantly higher than that of Hcy＜10 μmol/L group,and the level of high density lipoprotein cholesterol(HDL-C)was significantly lower than that of Hcy＜10 μmol/L group,and the differences were statistically significant(P＜0.05).(2)With cfPWV＞14 m/s as the boundary value,there was no significant difference in sex,course of disease,complica-tions,medication history,smoking history and drinking history in the two groups(P＞0.05).The level of age,Hcy,SBP,DBP,TC,TG and LDL-C in group cfPWV＞14 m/s was significantly higher than that in cfPWV ＜14 group.The difference was statistically significant(P＜0.05).(3)The correlation between serum level of Hcy and cfPWV,SBP/DBP,TC,TG,LDL-C and HDL-C showed that there was no correlation between serum Hcy and TC,TG,LDL-C,HDL-C levels(P＞0.05).However,serum Hcy was positively correlated with cfP-WV and SBP/DBP(r＝0.633,0.341,P＜0.05).(4)cfPWV correlated positively with age,Hcy,SBP/DBP,TC,TG,LDL-C,HDL-C(r＝0.251,0.622,0.347,0.427,0.288,0.339,P＜0.05),cfPWV correlated negative-ly with HDL-C(r＝ －0.479,P＜0.05).(5)The multiple regression analysis of patients with age ＞50 years,Hcy＞10 μmol/L,SBP＞130 mm Hg,LDL-C＞3.12 mmol/L and cfPWV showed that the age of 50 years old,Hcy＞10 μmol/L,SBP＞130 mm Hg,LDL-C＞3.12 mmol/L were all independent risk factors.Conclusion The high Hcy level of serum in young and middle RH patients is an independent risk factor for cfPWV,which can accelerate the progress of arteriosclerosis,and it is necessary for clinicians to pay attention to the treat-ment process.关键词
同型半胱氨酸/难治性高血压/颈-股动脉脉搏传导进度/动脉硬化Key words
homocysteine/refractory hypertension/carotid femoral artery pulse conduction velocity/arterial stiffness分类
医药卫生
