检验医学与临床2018，Vol.15Issue(12)：1749-1752,4.DOI:10.3969／j.issn.1672-9455.2018.12.015
冠状动脉粥样硬化患者血脂及修饰化脂蛋白水平研究
Study on the blood lipid and the modified lipoprotein level in patients with coronary atherosclerosis
摘要
Abstract
Objective To analyze the levels of serum lipid,modified lipoprotein and lipoprotein related phospholipase A2 in patients with coronary atherosclerosis,and to explore the relationship between modified lipoprotein and lipoprotein related phospholipase A 2 and the occurrence of coronary atherosclerosis.Methods A total of 220 cases who came to Emergency Department of West China Hospital from September 2016 to De-cember 2016 due to acute myocardial infarction and were diagnosed as coronary atherosclerotic were taken as a case group,200 healthy individual were taken as a control group.The differences of serum lipids and modified lipoprotein levels between case group and control group were compared.Results The fasting blood glucose and glycated hemoglobin in the case group were higher than those of the control group(P＜0.05).There was no significant difference on the level of triacylglycerol(P＞0.05).The levels of cholesterol,high density lipo-protein cholesterol and low density lipoprotein cholesterol in the case group were lower than those in the con-trol group,and the differences were statistically significant(P＜0.05).The levels of oxidized low density lipo-protein,oxidized high density lipoprotein,glycosylatedlow density lipoprotein,glycosylated high density lipo-protein and lipoprotein related phospholipase A 2 in the case group were all higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Blood lipid is not a major factor in the occurrence and development of coronary atherosclerosis.Hyperglycemia,high level of modified lipoprotein and lipoprotein related phospholipase A2 are closely related to the formation of coronary atherosclerosis.关键词
心肌梗死/冠状动脉粥样硬化/修饰化脂蛋白/脂蛋白相关磷脂酶A2Key words
myocardial infarction/coronary atherosclerosis/modified lipoprotein/lipoprotein related phospholipase A2分类
医药卫生引用本文复制引用
罗薇,郭英,都向阳,丁霏,李小玲,贺勇,聂鑫,宋昊岚,李贵星..冠状动脉粥样硬化患者血脂及修饰化脂蛋白水平研究[J].检验医学与临床,2018,15(12):1749-1752,4.基金项目
四川省科技支撑项目(2016SC0044). （2016SC0044）
