摘要
Abstract
Objective To observe curative efficacy of metformin in combination with aerobic exercise of moderate intensity in patients of type 2 diabetes mellitus(T2DM)complicated with nonalcoholic fatty liver disease(NAFLD).Methods A total of 140 patients of T2DM complicated with NAFLD admitted in the hos-pital from January 2016 to December 2016,meeting the inclusion criteria were divided into control group and observation group with random number method,70 cases in each group.The control group was treated with metformin,while the observation group was treated with metformin in combination with aerobic exercise of moderate intensity.Liver function index,blood lipid index,body mass index(BMI),insulin resistance index(HOMA-IR)and adiponectin level were compared between the two groups.Results In comparison with the control group,the observation group had lower levels of liver function indexes of alanine transaminasa(ALT),aspartate transaminase(AST),glutamyl transpeptidase(GGT),lower levels of blood lipids indices of total cholesterol(TC),triglyceride(TG),lower BMI,lower level of HOMA-IR and higher level of adiponec-tin,and the differences were statistically significant(P＜0.05).Conclusion Metformin in combination with aerobic exercise of moderate intensity has good effect in patients of T 2DM complicated with NAFLD.It can ef-fectively ameliorate levels of liver function,blood lipids,reduce bodyweight,and increase the level of adiponec-tin,which is worthy of clinical application.关键词
二甲双胍/有氧运动/2型糖尿病/非酒精性脂肪肝/肝功能/血脂/脂联素Key words
metformin/aerobic exercise/type 2 diabetes mellitus/nonalcoholic fatty liver disease/liver function/blood lipids/adiponectin分类
医药卫生
