检验医学与临床2018，Vol.15Issue(12)：1789-1791,1795,4.DOI:10.3969／j.issn.1672-9455.2018.12.027
乳腺癌组织中人乳腺球蛋白的表达水平及其与乳腺癌发生和发展的关系
Expression of human mammary globulin in breast cancer tissues and its relationship with the occurrence and development of breast cancer
王刚 1廖翠屏 1刘敏 1温亚楠1
作者信息
- 1. 四川省成都市温江区妇幼保健院检验科 611130
- 折叠
摘要
Abstract
Objective To study the expression of human mammary globulin in breast cancer and its rela-tionship with the occurrence and development of breast cancer.Methods The breast cancer tissues(group A)and adjacent normal tissues(group B)and benign breast lesion tissues(group C)were selected in the hospi-tal,with 40 cases in each group.The the expression levels of human mammary globulin in the three groups were determined by tissue microarray technique and immunohistochemistry,and the human mammary globulin mRNA expression in the three groups was determined by reverse transcription polymerase chain reaction.The expression of human mammary globulin and its mRNA were compared among the three groups.Results The positive rate of human mammary globulin in the group A was significantly higher than that in the group B and group C,and the expression level of mRNA in the group A was significantly higher than those in the group B and group C(P＜0.05),but there was no significant difference between group B and group C(P＞0.05).The expression of human mammary globulin in breast cancer tissues was significantly related to histological grade,lymph node metastasis and estrogen receptor(ER)(P＜ 0.05),but had no significant correlation with the pathological type,TNM stage,tumor size and progesterone receptor(PR)(P＞0.05).Multivariate Logistic regression analysis showed that there were significant correlation between the expression of human breast globulin and histological grade,PR and ER(P＜ 0.05).Conclusion Human mammary globulin shows high expression levels in breast cancer tissues,and it is significant correlated to the histological grade,PR and ER,indicating that it may be involved in the pathogenesis of the breast cancer,so it can be used as an important in-dex to evaluate the tumor invasion and malignant degree of breast cancer.关键词
乳腺癌/乳腺良性病变/人乳腺球蛋白Key words
breast cancer/benign breast lesion/human mammary globulin分类
医药卫生引用本文复制引用
王刚,廖翠屏,刘敏,温亚楠..乳腺癌组织中人乳腺球蛋白的表达水平及其与乳腺癌发生和发展的关系[J].检验医学与临床,2018,15(12):1789-1791,1795,4.
