检验医学与临床2018，Vol.15Issue(13)：1885-1888,4.DOI:10.3969/j.issn.1672-9455.2018.13.006
瘦素、IL-6、IL-17、IL-23在强直性脊柱炎患者中的表达及意义
Expression and its clinical significance of serum Leptin,IL-6,IL-17 and IL-23 in patients with ankylosing spondylitis
摘要
Abstract
Objective To investigate the clinical significance of leptin ,LP ,IL-6 ,IL-17 and IL-23 in patients with ankylosing spondylitis (AS).Methods Forty patients with AS were selected and divided into different groups with 3 different ways .They were divided into Bath AS disease activity index (BASDAI)≤4 scores (stable) group and BASDAI ＞ 4 scores (active) group ;They were divided into 4 groups-Ⅰ,Ⅱ,≥ Ⅲ with the CT result of sacroiliac joint .They were divided into positive and negative group with HLA-B27 .Another forty healthy persons were included as control group .And then test the serum levels of LP ,IL-6 ,IL-17 ,IL-23 and ESR ,CRP in all the subjects ,and the values were tested and compared between different groups .In addition , the relationship between various parameters ,serum immune index and those with BASDAI were further ana-lyzed .Results The serum levels of LP ,IL-6 ,IL-17 ,IL-23 of observation group patients were higher than nor-mal control group (P＜0 .05).The difference between them has statistical significance (P＜0 .05).The serum levels in active were higher than those in the stable group (P＜0 .05).According to the CT result of sacroiliac joint :the serum levels of LP ,IL-6 ,IL-17 ,IL-23 of patients with level Ⅰ and level Ⅱ were higher than normal control group (P＜0 .05).The difference of serum levels of LP ,IL-6 ,IL-17 ,IL-23 of patients between ≥ Ⅲlevel patients and normal control group has no statistical significance (P＞0 .05).The difference between pa-tients with level Ⅰ,level Ⅱ group and ≥ Ⅲ level group has statistical significance (P＜0 .05).The levels of LP ,IL-6 ,IL-17 ,IL-23 had no statistical significance between HLA-27 positive group and negative group (P＞0 .05).There was a positive correlation between LP ,IL-6 ,IL-17 ,IL-23 and ESR ,CRP ,BASDAI . Conclusion The serum levels of LP ,IL-6 ,IL-17 ,IL-23 in AS patients were significantly higher than healthy persons .And have positive relationship with disease activity indicators .关键词
强直性脊柱炎/瘦素/白细胞介素-6/白细胞介素-17/白细胞介素-23Key words
ankylosing spondylitis/leptin/interleukin-6/interleukin-17/interleukin-23分类
医药卫生引用本文复制引用
张征,常显,朱宁,许鸣华,魏凤菊,尚丽娜..瘦素、IL-6、IL-17、IL-23在强直性脊柱炎患者中的表达及意义[J].检验医学与临床,2018,15(13):1885-1888,4.基金项目
河北省保定市科学技术研究与发展指导计划资助项目(17ZF271) （17ZF271）
