检验医学与临床2018，Vol.15Issue(13)：1889-1891,3.DOI:10.3969/j.issn.1672-9455.2018.13.007
透明质酸、甲胎蛋白、甲胎蛋白异质体-3和高尔基蛋白73联合检测在肝脏疾病诊断中的价值
Diagnostic value of combinced detection of hyaluronic acid,alpha fetoprotein, alpha fetoprotein variants and golgin protein 73 for liver disease
摘要
Abstract
Objective To explore the diagnostic value of joint detection of hyaluronic acid (HA) ,alpha-fe-toprotein (AFP) ,alpha-fetoprotein variants (AFP-L3) and golgin protein 73 (GP73) in liver diseases . Methods A total of 36 patients with primary liver cancer ,46 cases of patients with cirrhosisa ,40 patients with chronic hepatitis admitted to our hospital from January 2013 to June 2016 ,as well as 50 healthy individuals , were included in the study .Serum levels of HA ,AFP ,AFP-L3 and GP73 were determined .Results Liver cancer group ,the levels of HA ,AFP ,AFP-L3 ,GP73 were obviously higher than those in the chronic hepatitis group ,the difference was statistically significant (P＜0 .05) ,the levels of AFP ,AFP-L3 in liver cancer group were higher than those in cirrhosis group ,the difference was statistically significant (P＜0.05) ,the levels of HA ,GP73 in liver cancer was no significant difference with cirrhosis group (P＞ 0 .05).The levels of HA , AFP ,AFP-L3 ,GP73 in cirrhosis group were obviously higher than those in the chronic hepatitis group ,the difference was statistically significant (P＜0 .05).In 36 cases of primary liver cancer patients ,the sensitivity and specific degree of AFP-L3 was obviously higher than that of other individual .The sensitivity and speciality rate of HA ,AFP ,AFP-L3 and GP73 combined diagnostic is higher than any other combination .Conclusion Increased HA and GP73 was related to hepatic impairment and chronic fibrosis and had a better sensitivity for the diagnosis of liver AFP-L3 better sensitivity in the diagnosis of liver cancer ,joint application of AFP-L3 and AFP could improve the diagnostic specificity of liver cancer .关键词
原发性肝癌/透明质酸/甲胎蛋白/甲胎蛋白异质体-3/高尔基蛋白73Key words
primary hepatocelluar carcinoma/hyaluronic acid/alpha fetoprotein/alpha fetoprotein variants-3/golgin protein 73分类
医药卫生引用本文复制引用
胡恒贵,秦淑国,欧雁冰,方高洁..透明质酸、甲胎蛋白、甲胎蛋白异质体-3和高尔基蛋白73联合检测在肝脏疾病诊断中的价值[J].检验医学与临床,2018,15(13):1889-1891,3.基金项目
安徽省宿州市皖北煤电集团总医院院级科研项目(SZ2012017) （SZ2012017）
