检验医学与临床2018，Vol.15Issue(13)：1896-1898,3.DOI:10.3969/j.issn.1672-9455.2018.13.009
不同剂量rhG-CSF对急性白血病患者化疗后白细胞水平的影响
Effects of different doses of rhG-CSF on the white blood cell in patients with acute leukemia after chemotherapy
熊涛 1张利铭 1张江召 1刘荟敏 1唐元艳 1黄知平1
作者信息
- 1. 湖北省荆州市中心医院/长江大学第二临床学院血液内科 434000
- 折叠
摘要
Abstract
Objective To investigate the effect of different doses of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the white blood cells in patients with acute leukemia after chemotherapy . Methods From January 2014 to May 2017 ,64 cases of acute leukemia patients in our hospital as the research object ,according to the order of admission were randomly divided into 3 groups ,the dosage of rhG-CSF in A group (high dose) of 400 μg/(m2·d) ,B group (middle dose) for 300 μg/(m2·d) ,C group (low dose) for 200 μg/(m2·d) ,course of 3 days .The 3 groups after chemotherapy were compared with minimum value of w hite blood cells (WBCmin) ,the highest value (WBCmax) ,WBC reduce time ;and after 2 cycles of chemotherapy using KPS score to evaluate the survival quality of patients ,record the application of antibiotics .Results Af-ter chemotherapy ,there were of no significant difference between the 3 groups in WBCmin and WBCmax( P＞0 .05) ;WBC reduce the time in A group was (1 .73 ± 0 .48) d ,significantly lower than that of group B [(3 .35 ± 1 .29)d] ,B group was lower than that of C group [(5 .84 ± 2 .62)d] ,the difference was of statistically significant (P＜0 .05) ;there was of no significant difference in KPS scores between 3 groups (P＞0 .05) ;the antibiotic use rate of group C (33 .33%) was significantly higher than that of group A (5 .56%) and group B (11 .11%) (P＜0 .05) ;but the B group and C group was of no statistical significance difference (P＞0 .05). Conclusion Middle and high dose of rhG-CSF can effectively shorten the period of white blood cell reduction in patients with acute leukemia chemotherapy ,and the therapeutic effect of medium dose and higher dose of rhG-CSF is equivalent ,which is more worthy of clinical recommendation .关键词
急性白血病/化疗/重组人粒细胞集落刺激因子/骨髓抑制Key words
acute leukemia/chemotherapy/recombinant human granulocyte colony stimulating factor /bone marrow suppression分类
医药卫生引用本文复制引用
熊涛,张利铭,张江召,刘荟敏,唐元艳,黄知平..不同剂量rhG-CSF对急性白血病患者化疗后白细胞水平的影响[J].检验医学与临床,2018,15(13):1896-1898,3.
