检验医学与临床2018，Vol.15Issue(13)：1910-1912,1916,4.DOI:10.3969/j.issn.1672-9455.2018.13.013
腹腔镜与开腹全结肠系膜切除术治疗右半结肠癌对细胞因子、肿瘤标志物及细胞免疫的影响
Effects of laparoscopic and open total mesorectal excision on cytokines,tumor markers and cellular immunity in right colon cancer
陈钢明 1张少华 1段丽 1刘小东 1汤涛1
作者信息
- 1. 湖北省武汉市第九医院普外科 430081
- 折叠
摘要
Abstract
Objective To study effects of laparoscopic and open total mesorectal excision on cytokines , tumor markers and cellular immunity in right colon cancer .Methods A total of 102 patients of Right colon cancer who received therapy from September 2013 to September 2015 in hospital were selected as research ob-jects .Laparoscopic total laparoscopic total mesorectal excision for laparoscopic total colorectalectomy .The in-flammatory cytokines (IL-6 ,MCP-1 ,HMGB-1) ,tumor markers (CCSA-2 ,MK ,VEGF ,PTN) and immune cells(Th1 ,Th2 ,Th17 ,CD4+/CD25+) were compared between the two groups .Results All the indexes of all patients before treatment were not statistically significant (P＞0 .05).After treatment ,the laparoscopic group of patients with four inflammatory cells :IL-6 ,MCP-1 ,HMGB-1 were lower than those in the open group (P＜0 .05) ;in contrast to tumor markers ,Laparoscopic group of patients CCSA-2 ,MK ,VEGF ,PTN also lower than those in the open group (P＜0 .05).In the comparison of immune cells ,Th2 and Th17 were lower in the abdominal cavity group than in the open group ,and Th1 and CD4+/CD25+ were higher than those in the con-trol group (P＜0 .05).Conclusion Laparoscopic total mesorectal excision can effectively inhibit inflammatory cytokines and tumor markers ,and can restore the immune cells ,more conducive to the treatment of patients .关键词
结肠癌/炎症细胞因子/肿瘤标志物/细胞免疫/腹腔镜Key words
colon cancer/inflammatory cytokines/tumor markers/immune cells/laparoscopy分类
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陈钢明,张少华,段丽,刘小东,汤涛..腹腔镜与开腹全结肠系膜切除术治疗右半结肠癌对细胞因子、肿瘤标志物及细胞免疫的影响[J].检验医学与临床,2018,15(13):1910-1912,1916,4.
