摘要
Abstract
Objective To investigate the levels of Th17 cells and cytokines in patients with atopic dermati-tis (AD) ,and to analyze the correlation between the level of Th17 cells and their cytokines and the degree of itching .Methods The clinical data of AD patients treated in our hospital from March 2015 to August 2016 were retrospectively analyzed .At the same time ,the healthy adults in our hospital were selected as the control group .To observe the difference of AD cell and cytokine levels in Th17 and control group ,AD patients with different degrees of pruritus ,and to analyze the correlation between pruritus score and Th17 cell and cytokine levels in patients with AD .Results The patients in the AD group of IL-4 ,IL-10 ,IL-17 ,IL-23 levels higher than the control group (P＜0 .01) ,there was no significant difference in INF-γ ,IL-21 and TGF-β level (P＞0 .05).There are significant differences between the levels of cytokines in different disease severity in patients with AD ,three patients with IL-4 ,IL-10 ,IL-17 and IL-23 levels from high to low are severe ,moderate and mild group ,no difference between the three groups of patients with INF-γ ,IL-21 and TGF-β levels .The SCO-RAD score of D patients was positively correlated with the levels of IL-4 ,IL-10 ,IL-17 and IL-23 ,and there was no significant correlation between the levels of INF-γ ,IL-21 and TGF-β.Conclusion The levels of IL-4 , IL-10 ,IL-17 and IL-23 were higher in patients with atopic dermatitis ,but the levels of INF-γ ,IL-21 and TGF-β were not different from those of normal controls ,and the level of cytokines in patients was closely related to the degree of itching .关键词
Th17细胞/特应性皮炎/细胞因子Key words
Th17 cell/atopic dermatitis/cytokine分类
医药卫生
