检验医学与临床2018，Vol.15Issue(13)：1920-1922,1926,4.DOI:10.3969/j.issn.1672-9455.2018.13.016
纳洛酮联合芬太尼对胃癌术后患者胃肠功能的影响
Effects of naloxone combined with fentanyl on gastrointestinal function in patients with gastric cancer
李砚文 1孔树佳 2肖云 1王永顺 1殷婕1
作者信息
- 1. 昆明医科大学第三附属医院/云南省肿瘤医院重症医学科,云南昆明650000
- 2. 昆明医科大学第三附属医院/云南省肿瘤医院药剂科,云南昆明650000
- 折叠
摘要
Abstract
Objective To investigate the effect of naloxone combined with fentanyl on gastrointestinal function in patients with gastric cancer .Methods From June 2012 to June 2016 ,86 patients with radical gas-trectomy were collected and randomly divided into observation group (n＝43) and control group (n＝43).Two groups of patients were given fentanyl intravenous-controlled analgesia .The observation group on this basis to give epidural injection of small doses of naloxone ,control given the same amount of saline injection .The VAS score ,postoperative bowel sounds recovery time ,defecation time ,anal exhaust time ,gastric motility recovery time and analgesic pump drug consumption and fentanyl dosage were compared between the two groups at dif-ferent time points .The incidence of disease was collected .Results The pain scores of the two groups were sig-nificantly lower than those of the control group at 4 h ,8 h ,12 h and 24 h after operation (P＜0 .05).The post-operative bowel disease .The time of analgesia ,defecation time ,anal exhaust time ,recovery time of gastric mo-tility and the consumption of analgesic pump and fentanyl were significantly lower than those of the control group in one week after operation .The total incidence of postoperative complications was 9 .30%,which was significantly lower than that of the control group (30 .23%) ,the difference was statistically significant (P＜0 .05).Conclusion Low dose of naloxone combined with fentanyl can reduce the dosage of analgesic drugs and reduce the side effects of opioids in patients with gastric cancer ,which is of great significance to the recovery of gastrointestinal function .With clinical promotion value .关键词
纳洛酮/芬太尼/胃癌/胃肠功能Key words
naloxone/fentanyl/gastric cancer/gastrointestinal function分类
医药卫生引用本文复制引用
李砚文,孔树佳,肖云,王永顺,殷婕..纳洛酮联合芬太尼对胃癌术后患者胃肠功能的影响[J].检验医学与临床,2018,15(13):1920-1922,1926,4.
