检验医学与临床2018，Vol.15Issue(13)：1930-1932,1935,4.DOI:10.3969/j.issn.1672-9455.2018.13.019
甲状腺全切除术联合同位素治疗乳头状甲状腺癌对患者MMP-2、MMP-9和PTEN的影响
Effects of total thyroidectomy combined with isotope therapy on MMP-2,MMP-9 and PTEN in patients with papillary thyroid carcinoma
张铁泉 1邓清 1乐问津 1鲁号峰 1黄强 1李宓1
作者信息
- 1. 湖北省荆州市第一人民医院肝胆外科 434000
- 折叠
摘要
Abstract
Objective To investigate the Effects of total thyroidectomy combined with isotope therapy on matrix metalloproteinase-2 (MMP-2) ,matrix metalloproteinase-9 (MMP-9) and homologous loss of phospha-tase on chromosome 10 in patients with papillary thyroid carcinoma-phosphatase and tensin homolog deleted from chromosome ten (PTEN) in patients with papillary thyroid carcinoma .Methods The clinical data of 45 patients with papillary thyroid carcinoma admitted from April 2014 to February 2015 were selected .The ex-pression of MMP-2 and MMP-9 and the levels of serum P53 ,PTEN and HIF-1α were measured before and af-ter treatment .The levels of MMP-2 and MMP-9 were measured before and after treatment .Results A total of 45 patients were successfully completed surgery ,intraoperative and hospital stay without patients died ,the to-tal effective rate of 95 .55%;6 patients with complications ,the incidence was 13 .33%;2 patients with tumor recurrence ,the incidence was 4 .44% .The expression of MMP-2 and MMP-9 in patients treated with treatment was significantly lower than that before treatment (P＜0 .05).The levels of P53 ,PTEN and HIF-1α in the pa-tients were significantly improved compared with those before treatment .The levels of serum P53 and HIF-1α were significantly lower than those before treatment ,while the level of PTEN was significantly higher than that before treatment statistically significant (P＜0 .05).Conclusion For papillary thyroid cancer patients , thyroidectomy combined with isotope has betten effect ,which could improve the expression of MMP-2 and MMP-9 in serum ,as well as the levels of serum P53 ,PTEN and HIF-1α and it has higher security .关键词
乳头状甲状腺癌/甲状腺全切除术/同位素/基质金属蛋白酶/第10号染色体同源丢失性磷酸酶-张力蛋白基因/缺氧诱导因子-1αKey words
papillary thyroid carcinoma/total thyroidectomy/isotope/therapeutic effect/PTEN /hypoxia duciblefactors-1α分类
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张铁泉,邓清,乐问津,鲁号峰,黄强,李宓..甲状腺全切除术联合同位素治疗乳头状甲状腺癌对患者MMP-2、MMP-9和PTEN的影响[J].检验医学与临床,2018,15(13):1930-1932,1935,4.
