昆明医科大学学报2018，Vol.39Issue(5)：11-15,5.
一个新颖的三七皂苷元衍生物及其抗肿瘤活性
A Novel Derivative of Panax Notoginseng Sapogenin and Its Antitumor Activity
摘要
Abstract
Objective To research the derivatives of panax notoginseng sapogenins and their anti-tumor activities. Methods The ginsenosides Rg1 was treated with Smith degradation. The products were separated and purified by silica gel column chromatography. The structures of the products were determined by NMR spectra. The activity of anti-tumor cells of compound (1) and 1'-hydroxyethanedioxy PT was detected with CDC25B activity assay and fluorescence technique. Results 1'-hydroxyethanedioxy PT , 20 (s)-protopanaxatriol (PT), and 24, 25 - en-3β, 6 α-dihydroxy-12, 20-(1', 2'-isopropylidenedioxy) propanedioxy-dammarane (1) were isolated and identified. Conclusion Compound (1), named 1',2'-isopropylidenedioxy-propanedioxy-pro-panedioxy , is a novel derivative of panax notoginseng sapogenin with better inhibitory activity against CDC25B.关键词
1’2’- 双氧异丙叉双氧丙基原人参三醇/三七总皂苷/Smith降解法/CDC25BKey words
1',2'-isopropylidenedioxy-propanedioxy-propanedioxy/Panax notoginseng saponins/Smith degradation/CDC25B分类
医药卫生引用本文复制引用
李瑞,段文越,邹澄,赵庆,黄丽,周金娜,胡建林,杨为民..一个新颖的三七皂苷元衍生物及其抗肿瘤活性[J].昆明医科大学学报,2018,39(5):11-15,5.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项重点基金资助项目[2017FE468(-001)] （-001）
昆明医科大学研究生创新基金资助项目(2017S070) （2017S070）
