昆明医科大学学报2018，Vol.39Issue(6)：66-70,5.
副肿瘤性周围神经病的神经电生理特点
Neuro Electrophysiological Characteristics of Paraneoplastic Peripheral Neuropathy
摘要
Abstract
Objective To study the neuro electrophysiological characteristics of paraneoplastic peripheral neuropathy (PPN) . Methods A retrospective study was conducted for 29 PPN patients consecutively referred to Neurology Department of the First Affiliated Hospital of Kunming Medical University between January 2000 and June 2017. The electrophysiological characteristics of motor nerves, sensory nerves of upper and lower limbs were analyzed. Measurement indicators include: (1) The motor conduction velocity and compound muscle action potential amplitude of median, ulnar, tibial, and common peroneal nerves; (2) The sensory conduction velocity and sensory nerve action potential amplitude of median, ulnar, tibial, and superficial peroneal nerves;(3) F waves of median and tibial nerves.Results (1) For patients with PPN, their motor and sensory nerves in upper and lower limbs were damaged. The total anomaly rate of the amplitude was higher than that of the nerve conduction velocity (P＜0.05), while the abnormal rate of amplitude of sensory nerve action potential was greater than that of motor nerve compound muscle action potential (P＜0.05) . Abnormal motor nerve conduction velocity had a similar incidence to abnormal sensory nerve conduction velocity (P＞0.05) . (2) Nerve conduction study showed that abnormality rate of lower extremity is higher than that of upper extremity. (3) Abnormal F waves were observed less frequently than abnormal nerve conduction rates (P＜0.05) . Conclusions The electrophysiological properties of PPN were frequently seen in sensorimotor neuropathy. The damage of distal extremities is more serious. The damage in lower extremity is more severe than that in the upper extremity. The axonal damage mainly occurred in sensory nerves. There is no obvious difference in the degree of demyelination between motor and sensory nerves. Evidence can be provided by analyzing the neuro ectrophysiological characteristics for diagnosis of paraneoplastic peripheral neuropathy in early stage.关键词
副肿瘤性周围神经病/神经电生理/特点Key words
Paraneoplastic peripheral neuropathy/Neuro electrophysiology/Characteristics分类
医药卫生引用本文复制引用
王丹,韦焘,段尉梅,韩娟,钟莲梅..副肿瘤性周围神经病的神经电生理特点[J].昆明医科大学学报,2018,39(6):66-70,5.基金项目
昆明医科大学"十三五"校级学科建设项目图书情报与档案管理(J1301826) （J1301826）
云南省科技厅－ 昆明医科大学应用基础研究联合专项基金资助项目 （）
