临床与实验病理学杂志2018，Vol.34Issue(1)：12-15,4.DOI:10.13315/j.cnki.cjcep.2018.01.004
乳腺癌新辅助化疗前后病理组织学及分子指标变化
Changes of histopathology and molecular indicators in breast cancer after neoadjuvant chemotherapy
摘要
Abstract
Purpose To observe the changes of histopathology and expression levels of ER, PR, HER-2 and Ki-67 in breast cancer after neoadjuvant chemotherapy (NTC), and to evaluate the relationship between the curative effect and clinico-pathological characteristics of breast cancer. Methods 93 ca-ses of invasive breast cancer with NTC were collected and retro-spectively analyzed. Pathologic evaluation of chemotherapeutic effect were evaluated by Miller-Payne (MP) grading system. Results Tumor cells, tumor stroma and lymph nodes status presented different histopathological changes after NTC. There were significant relationship between curative effect and patients age (Z=-1.993, P=0.046 ), histological grade (χ2=7.261, P=0.027), molecular subtypes (χ2=8.289, P=0.040), while it had no statistical relationship between curative effect and tumor size (Z=-1.091, P=0.275) and lymph node status (Z=-1.107, P = 0.268). Expression of ER, PR, HER-2 and Ki-67 showed different degrees of change before and after NTC. The concordance rates of ER, PR, HER-2 and Ki-67 were 81.0％, 72.2％, 83.5％ and 55.7％, respective-ly. And there was no significant difference in expression of these four molecular indicators before and after NTC (χ2 =0.428, P=0.934). Conclusion The histomorphology of tumor cell, tumor stroma and lymph node status can be influenced by NTC. Objective evaluation of the changes of histopathology and molecular indicators after NTC may valuable in predicting clinical prognosis and guiding individual treatment of breast cancer.关键词
乳腺肿瘤/新辅助化疗/病理学/分子指标Key words
breast neoplasm/neoadjuvant chemotherapy/pathology/molecular indicator分类
医药卫生引用本文复制引用
汤红平,荣磊,梁冠男,陈国艳,魏欣,黄新翼..乳腺癌新辅助化疗前后病理组织学及分子指标变化[J].临床与实验病理学杂志,2018,34(1):12-15,4.基金项目
深圳市科技计划(JCYJ20160427190318822) （JCYJ20160427190318822）
