临床与实验病理学杂志2018，Vol.34Issue(1)：16-21,6.DOI:10.13315/j.cnki.cjcep.2018.01.005
三阴型乳腺癌中S1PR1、S1PR4的表达及其临床意义
Expression of S1PRl,S1PR4 in triple negative breast carcinoma and its significance
摘要
Abstract
Purpose To investigate the expression of sphingosine-1 phosphate receptor 1 (S1PR1) and sphingosine-1 phosphate receptor 4 (SIPR4) in triple negative breast carcinoma (TNBC) and to evaluate its correlation with the clinicopathologic features of TNBC. Methods 72 cases of tissue slides of TNBC were stained immunohistochemically and analyzed with image processing to calculate the S1PR1 and S1PR4 expression. Correlations of the S1PR1 and S1PR4 expression with the clinicopathologic features of TNBC were studied. Results Ki-67 index of high, moderate and low expression of the S1PR1 in TNBC were 48.89％, 36.11％ and 26.48％, respectively. The difference among them was significance (P＜0.001). Ki-67 index of high, moderate and low expression of the S1PR4 in TNBC were42.83％, 31.43％ and 28.93％, respectively. The difference among them was significance (P = 0.007 ). The positive rate of lymph node of high, moderate and low expression of the SI PR1 in TNBC were 31.4％, 48.6％ and 20.0％, respectively. The difference among them was significance (P = 0.012). The positive rate of lymph node of high, moderate and low expression of the S1PR4 in TNBC were 54.3％, 40.0％ and 5.7％, respectively. The difference among them was significance (P=0.010). The CD68 positive rate of high, moderate and low expression of the S1PR1 in TNBC were 47.22％, 42.59％ and31.48％, respectively. The difference among them was significance (P = 0.036). Both the difference of survive rate among high, moderate and low expression of the S1PR1 and S1PR4 were not significance (P = 0.209 and P =0.593 ). Conclusion High expression of S1PR1 and S1PR4 may contribute to the cellular proliferation and lymph node metastases in TNBC. The survive rate of TNBC maybe not related with both the S1PR1 and S1PR4 expression.关键词
乳腺肿瘤/1-磷酸神经鞘氨醇受体/免疫组织化学/鉴别诊断Key words
breast neoplasm/sphingosine-1 phosphate receptor/immunohistochemistry/differential diagnosis分类
医药卫生引用本文复制引用
王娟,邬万新,陈彩萍,郭志琴,王振,陆宁,温晓伟..三阴型乳腺癌中S1PR1、S1PR4的表达及其临床意义[J].临床与实验病理学杂志,2018,34(1):16-21,6.基金项目
嘉兴市科技计划(2017BY18009) （2017BY18009）
