临床与实验病理学杂志2018，Vol.34Issue(1)：37-41,5.DOI:10.13315/j.cnki.cjcep.2018.01.009
鼻腔鼻窦原发分泌性癌2例临床病理学观察
Sinonasal mammary analogue secretory carcinoma: a clinicopathological analysis of 2 cases
摘要
Abstract
Purpose To investigate the clinicopathological features of sinonasal primary secretory carcinoma (SC) and its diagnosis, differential diagnosis. Methods Two cases of sin-nasal SC were analyzed by light microscopy with immunohisto-chemical staining (EnVision) for CK, vimentin, S-100 protein, SOX10, PAS, DPAS, Mamaglobin, Calponin, DOG1, p63 and molecular detection of ETV6 gene break. Results Morphologically, SC revealed varying proportions of solid, tubular, acinar, microcystic, tubular growth patterns. All SC cases were cytological low grade with uniform cells, small-to medium-sizes nuclei, occasional small nucleoli, and abundant pink, bubbly cytoplasm. Mitotic figures were rarely encountered. Tumor cells secreted eosinophilic, colloid-like secretions that were PAS positive. There were no DPAS positive zymogen granules in cyto-plasm. This tumor cells were CK, vimentin, S-100, SOX10, PAS positive and Mamaglobin, Calponin and p63 negative. The ETV6 gene rearrangement was confirmed in all cases by fluorescence in situ hybridization (FISH). After excision, all two patients were survival without tumor recurrence for 41 months and53 months. Conclusion Sinonasal primary SC is a low grade malignant tumor. The histological features of SC are overlap with other salivary gland tumors. Immunohistochemical analysis and FISH are useful for the diagnosis and differential diagnosis.关键词
鼻腔肿瘤/分泌性癌/临床病理/鉴别诊断Key words
sinonasal neoplasm/secretory carcinoma/clinical pathology/differential diagnosis分类
医药卫生引用本文复制引用
岳常丽,董格红,赵晓丽,韩一丁,赵艺哗,刘红刚..鼻腔鼻窦原发分泌性癌2例临床病理学观察[J].临床与实验病理学杂志,2018,34(1):37-41,5.基金项目
首都临床特色应用研究、北京市市科委生物医药处(2016,6-2019,6) （2016,6-2019,6）
