临床与实验病理学杂志2018，Vol.34Issue(1)：50-54,5.DOI:10.13315/j.cnki.cjcep.2018.01.012
口腔鳞状细胞癌中VaSohibin-l、LGR5表达及临床意义
Expression of Vasohibin-1 and LGR5 in oral squamous cell carcinoma and their clinical significances
摘要
Abstract
Purpose To detect the expression of vasohibin-1 (VASH-1) and LGR5 protein in oral squamous cell carcinoma(OSCC) and their clinical significances. Methods Expression of VASH-1 and LGR5 protein in 223 cases of OSCC tissues and 80 cases of adjacent normal oral mucosa tissues was examined by the immunohistochemicalEliVision method. Results The positive rate of VASH-1 and LGR5 protein in OSCC tissues and the control tissues was 59.6％, 55.6％ and 12.5％, 13.8％, respectively. There was a significant difference between the two groups (P＜ 0.05 ). The expression of VASH-1 and LGR5 protein was significantly related with grades of tumors, size of tumors, lymph node metastasis, and TNM stages (all P＜0.05). The positive expression of VASH-1 and LGR5 was not relevant to age, gender, location of tumor, smoking, and alcohol (all P＞ 0.05). Spearman correlation analysis showed that there was a positive association between the VASH-1 expression and LGR5 expression (rs =0.718, P＜0.001). Conclusion The expression of VASH-1 and LGR5 in OSCC is high and may promote the initiation and development of the cancer, which play an important role in the invasion, metastasis, and prognosis of OSCC.关键词
口腔肿瘤/Vasohibin-1/LGR5/免疫组织化学Key words
oral neoplasm/vasohibin-1/LGR5/immunohistochemistry分类
医药卫生引用本文复制引用
吴志刚,杨东昆,刘畅,洪虓,俞岚..口腔鳞状细胞癌中VaSohibin-l、LGR5表达及临床意义[J].临床与实验病理学杂志,2018,34(1):50-54,5.基金项目
安徽省教育厅重点项目(KJ2017A224) （KJ2017A224）
