临床与实验病理学杂志2018，Vol.34Issue(1)：60-64,5.DOI:10.13315/j.cnki.cjcep.2018.01.014
甲状腺血管内大B细胞淋巴瘤并文献复习
Intravascular large B cell lymphoma of thyroid gland and review of literature
陈佳梅 1李文鹤 2刘杰 2曾盼 2谢永辉 2章宏峰 2罗波2
作者信息
- 1. 武汉大学人民医院肿瘤科,武汉 430060
- 2. 华中科技大学同济医学院附属武汉市中心医院病理科,武汉 430014
- 折叠
摘要
Abstract
Purpose To investigate the clinical-pathological characteristics of the primary thyroid intravascular large B-cell lymphoma (PT-IVLBCL). Methods The clinical-patho-logical data of the PT-IVLBCL were analyzed retrospective. A comprehensive analysis of the literature on IVLBCL published between 1991-2017 in China were performed. Results A thy-roid mass was identified in a physical examination of a 68-year-old male who initially presented with dyspnea accompanied by intermittent headache for about 1 month. Pathological results showed that large atypical lymphoma-like cells filled the small vessel capillaries in the lesion area. Immunohistochemical staining revealed that the lymphoma-like cells were positive for CD20, Pax-5, BCL-2 and MUM1. The Ki-67 index was estimated to be approximately 85％. Conclusion IVLBCL is a rare and aggressive disease that is easy to be misdiagnosed or missed, because it's clinical presentations are non-specific. The correct diagnosis depends on pathology. IVLBCL is known for its rapid progression and poor prognosis, but timely diagnosis and treatment with chemotherapy can improve patients survival.关键词
血管内淋巴瘤/大B细胞/甲状腺/结节性甲状腺肿Key words
intravascular lymphoma/large B-cell/thyroid/nodular goiter分类
医药卫生引用本文复制引用
陈佳梅,李文鹤,刘杰,曾盼,谢永辉,章宏峰,罗波..甲状腺血管内大B细胞淋巴瘤并文献复习[J].临床与实验病理学杂志,2018,34(1):60-64,5.
