临床与实验病理学杂志2018，Vol.34Issue(1)：65-68,4.DOI:10.13315/j.cnki.cjcep.2018.01.015
食管黏膜原发性Paget病临床病理分析
Clinicopathologic study of pimary paget disease in esophagus
摘要
Abstract
Purpose To investigate the clinicopathological and diagnostic characteristics of primary Paget disease (PD ) in esophagus. Methods The clinical presentation, histological observation and immunohistochemical staining were analyzed in four cases of primary PD involved esophagus and related literatures were reviewed. Results The patients were all male, aged from 61 to 74 years old. All the tumors were originated from the mucosa of the esophagus. Histologically, the Paget cells showed a single or small nesting and acinar distribution in the esophage-al mucosa. Adenocarcinoma in situ were seen in 2 cases and squamous cell carcinoma was seen in one of them. Immunohisto-chemically, the Paget cells were typically strongly positive for Ckpan, CKL, and CK7, while negative for CKH, CK5/6, CK14, p63. Conclusion Primary esophagus PD is rare. It can develop alone in esophagus or accompanied with adenocarcinoma in situ, invasive squamous cell carcinoma. The correct diagnosis need detailed pathological observation, immunohistochemical ev-idence and medical history.关键词
Paget病/食管黏膜/鉴别诊断/免疫组织化学Key words
Paget disease/esophagus/differential diagnosis/immunohistochemistry分类
医药卫生引用本文复制引用
黎喜梅,张智弘,范钦和,潘敏鸿..食管黏膜原发性Paget病临床病理分析[J].临床与实验病理学杂志,2018,34(1):65-68,4.基金项目
福建省卫生厅青年科研课题(2012-2-93)、厦门市卫计委科技项目(2011S0408) （2012-2-93）
