临床与实验病理学杂志2018，Vol.34Issue(6)：619-623,5.DOI:10.13315/j.cnki.cjcep.2018.06.007
尤因肉瘤中细胞骨架结合蛋白4.1N的表达及其临床意义
Expression of cytoskeletal binding protein 4. 1N in Ewing's sarcoma and its clinical significance
摘要
Abstract
Purpose To investigate the expression of cy-toskeletal protein 4. 1N in Ewing's sarcoma and the correlation with cell proliferation as well as clinicopathological characteris-tics. Methods Immunohistochemical EnVision two-step stai- ning was used to detect the expression of 4. 1N in 52 Ewing's sarcoma cases, which 47 cases of them were performed to detect the expression of Ki-67. The relationship between the expression of 4. 1N and Ki-67, and the correlation with the pathological fea- tures including prognosis were analyzed. Results The positive expression of 4. 1N was found in 35% (18/52) of Ewing's sar-coma. Lower frequency of 4. 1N strong expression (1. 9% , 1/52) was detected in the cohort. Ki-67 labeling index in Ewing's sarcoma varied from 3% to 85% . 4. 1N expression displayed a negative correlation with Ki-67 index ( P ＜0. 05). Among the follow-up of 27 cases, Kaplan-Meier survival analysis suggested that patients with 4. 1N-negative had shorter survival period than patients with 4. 1N positive expression (P ＜0. 05). However, the expression of 4. 1N was not statistically correlated with sex, age, tumor's localization and metastasis. Conclusion 4. 1N mainly showed negative or lower expression in Ewing's sarcoma and was related to cell proliferation index Ki-67, which implied a potential function in regulating proliferation in Ewing's sarcoma. 4. 1N expression has potentially predictive value in outcome of E-wing's sarcoma.关键词
尤因肉瘤/4. 1N/Ki-67/免疫组织化学/临床病理Key words
Ewing's sarcoma/4. 1N/Ki-67/immunohisto-chemistry/clinicpathologic features分类
医药卫生引用本文复制引用
张伟文,周小婷,高菲,安秀丽,王华..尤因肉瘤中细胞骨架结合蛋白4.1N的表达及其临床意义[J].临床与实验病理学杂志,2018,34(6):619-623,5.基金项目
国家自然科学基金(81272945 )、北京市自然科学基金(7122100) （81272945 ）
