中国临床保健杂志2018，Vol.21Issue(3)：302-304,3.DOI:10.3969/J.issn.1672－6790.2018.03.004
氨磷汀对恶性肿瘤化疗患者肝脏保护作用的临床观察
Observation on amifostine for the protection of hepatic toxicity in malignant tumor chemotherapy patients
摘要
Abstract
Objective To observe the protection of hepatic toxicity by amifostine in malignant tumor patients receiving chemotherapy.Methods 100 cases had history of drug－induced liver injury were randomly divided into exper－imental group and control group.There were 50 cases in each group.The experimental group received amifostine before chemotherapy,while the control group received 7 days magnesium isoglycyrrhizinate from the beginning of chemotherapy. All patients were examined before chemotherapy and 10 days after therapy,including liver function markers of ALT , AST,ALP and TBIL.Results The incidence of liver damage in experimental group and the control group were 12 (24.0%) and 28 (56.0%),respectively.The difference was statistically significant between the two groups (χ2＝10.667,P＝0.001).ALT,AST,ALP,TBIL were detected 10 days after chemotherapy.The experimental group′s ALT and AST are statistically lower than those in control group (P＝0.038,P＝0.013).But there was no significant differ－ence btween experimental group and control group about ALP and TBIL (P＝0.907,P＝0.248).Conclusion Amifos－tine is effective in protecting the injury of hepatic function caused by chemotherapy .关键词
肿瘤/药物疗法/药物性肝损伤/氨磷汀Key words
Neoplasms/drug therapy/Drug－induced liver injury/Amifostine分类
医药卫生引用本文复制引用
姚艺玮,王勇,何义富,罗会芹,胡冰,季楚舒..氨磷汀对恶性肿瘤化疗患者肝脏保护作用的临床观察[J].中国临床保健杂志,2018,21(3):302-304,3.基金项目
国家自然科学基金(81472329) （81472329）
