中国临床保健杂志2018，Vol.21Issue(3)：305-309,5.DOI:10.3969/J.issn.1672－6790.2018.03.005
新风胶囊对活动期类风湿关节炎脂蛋白代谢的影响
Effect of Xinfeng Capsule on lipo－protein metabolism in patients with active rheumatoid arthritis
摘要
Abstract
Objective To study the effect of Xinfeng Capsule (XFC) on lipo－protein metabolism in patients with active rheumatoid arthritis (RA).Methods Sixty－five patients with active RA were divided into the treating group with 40 patients(XFC group),the control group with 25 patients(MTX group) and the normal group (NC) including 20 healthy subjects according to the random number table.The changes in lipoprotein index ,clinical efficacy ,lipid metabo－lism,symptoms and signs of arthrosis and the changes and correlation analysis of activity index of patients in each group were observed.Results Compared with those of the NC group,the prealbumin (PA),total protein (TP),albumin (ALB),high density lipoprotein (HDL) and ApolipoproteinA1 (ApoA1) of the simple RA group and the combined RA group significantly decreased (P＜0.05).Compared with those of the combined RA group ,the TP and GLO of the sim－ple RA group significantly increased (P＜0.05) while ApoB significantly decreased.HDL was positively correlated with IgM,and negatively correlated with ESR and CRP (P＜0.05).ApoA1 was positively correlated with IgM and C3 and negatively correlated with ESR ,CRP and arthritis(P＜0.05).No significant difference was shown between the general efficiency of the two groups(P＞0.05),but the marked effective rate of the treatment group was higher than that of the control group(P＜0.05).There was no significant difference between the pre－treatment clinical index of the two treat－ment groups(P＞0.05);compared with the conditions before treatment ,both treatments can significantly lower ASO , ESR,CRP,α－AGP and RF and significantly attenuate arthralgia ,arthrocele,joint tenderness and time of morning stiffness (P＜0.05 or P＜0.01).Compared with the pre－treatment index,PA,HDL,ApoA1 and ApoB of the treatment group sig－nificantly increased(P＜0.05 or P＜0.01);but in the control group,there was no significant change in all the index (P＞0.05)except a significant increase of PA(P＜0.01).Compared with the control group,the treatment group showed that PA significantly increased,ESR significantly decreased and the effect in improving arthralgia ,arthrocele,joint ten－derness and time of morning stiffness was significantly superior to that of the control group (P＜0.05 or P＜0.01).Con－clusion The abnormality of lipoprotein metabolism exists in RA patients.XFC can improve immunity and guard against inflammation,increase lipoprotein metabolism by modulating the balance of cytokines .关键词
关节炎,类风湿/蛋白平衡缺陷/炎症趋化因子类/中草药Key words
Arthritis,rheumatoid/Proteostasis deficiencies/Chemokines/Drugs,Chinese herbal分类
医药卫生引用本文复制引用
潘喻珍,刘健,俞红五,朱艳,吴炳坤,杨佳,曹云燕,胡雪..新风胶囊对活动期类风湿关节炎脂蛋白代谢的影响[J].中国临床保健杂志,2018,21(3):305-309,5.基金项目
国家青年自然科学基金(81403484) （81403484）
