中国临床保健杂志2018，Vol.21Issue(3)：323-327,5.DOI:10.3969/J.issn.1672－6790.2018.03.010
原发性高血压伴血脂异常患者的动态血压特点
The characteristics of ambulatory blood pressure in patients with essential hypertension and dyslipidemia
摘要
Abstract
Objective To analyze the characteristics of ambulatory blood pressure in patients with essential hy － pertension and dyslipidemia ,and investigate the relationship between abnormal lipid metabolism and blood pressure vari－ability.Methods 150 patients with essential hypertension (EH) were selected and divided into the normal lipid group and the hyperlipidemia group according to the level of LDL－C:LDL－C＜3.4 mmol/L;LDL－C≥3.4 mmol/L,after meas－uring dynamic blood pressure and low density lipoprotein cholesterol (LDL－C) level.And we tested lipid indexes,col－lected and calculated a series of dynamic parameters of blood pressure for comparison .Results Compared with the nor－mal lipid group,24hour mean systolic blood pressure(24hMSBP) [(149.60 ±5.70)mm Hg vs (139.93 ±4.18)mm Hg],day mean systolic blood pressure (dMSBP) [(152.60 ±5.7)mm Hg vs (142.86 ±4.41)mm Hg],night mean systolic blood pressure (nMSBP) [(147.52 ±6.05)mm Hg vs (134.88 ±5.70)mm Hg],24 hour systolic blood varia－bility (24hSBPV) [(12.33 ±0.89)mm Hg vs (9.70 ±0.58)mm Hg],day systolic blood variability (dSBPV) [(10.72 ±2.24)mm Hg vs (9.46 ±0.63)mm Hg],night systolic blood variability(nSBPV) [(10.49 ±1.88)mm Hg vs (9.13 ±0.69)mm Hg] and morning systolic blood pressure surge [(35.53 ±2.98)mm Hg vs (27.29 ±3.38)mm Hg] in the dyslipidemia group were both higher ,and the difference were statistically significant (P＜0.05).The dyslip－idemia group mostly showed ＂non－dipper type＂blood pressures (66.67%vs.28.00%).Blood pressure variability was positively correlated with LDL－C (r＝0.342) and triacylglycerol (r＝0.831),but negatively correlated with high－densi－ty lipoprotein cholesterol (r＝－0.225).Conclusion The increase of LDL－C can affect blood pressure value and the rhythm of blood pressure day and night in patients with essential hypertension ;lipid metabolism is related to blood pres－sure variability in patients with essential hypertension.关键词
高血压/血脂异常/血压变异性/非杓型血压Key words
Hypertension/Dyslipidemias/Blood pressure determination/Circadian rhythm分类
医药卫生引用本文复制引用
孟亚星,张小玲,严激..原发性高血压伴血脂异常患者的动态血压特点[J].中国临床保健杂志,2018,21(3):323-327,5.基金项目
安徽省科技厅年度攻关项目(11070403049 ) （11070403049 ）
