中医药治疗干眼疗效的Meta分析
Meta analysis of traditional Chinese medicine in the treatment of dry eye in recent years
摘要
Abstract
· AIM:To evaluate the traditional Chinese medicine (TCM) for the treatment of dry eye effect in the past five years by using meta analysis method.· METHODS:According to the Cochrane evaluation system method,we searched Medline (January 2013 to October 2017),EMbase (2013-2017),Cochrane Library (2017),Wanfang database (2013-2017),VIP (2013-2017),and CNKI(2013-2017) for studies published.We included randomized controlled trials conducted the TCM in the treatment of dry eye.RevMan 5.0 statistical software data extraction and Meta analysis were conducted.· RESULTS:A total of 10 studies were identified,nine were from Chinese literature and one was from English literature,of which including 1 229 eyes.Nine of these studies performed BUT measurements at the end of the course of treatment.The results showed a statistically significant difference (P ＜ 0.00001).Nine studies performed tear flow measurements at the end of the course of treatment and the results showed a statistically significant difference (P ＜ 0.0001).Two studies performed FL measurements after the end of the course of treatment;the results showed no statistically significant difference (P=0.25).Three studies performed dry eye symptoms after the end of the course of treatment;the results showed that the differences were statistically significant (P=0.0003);the overall efficacy comparison,the difference between the two groups was statistically significant (P＜0.00001).· CONCLUSION:TCM treatment can significantly prolong BUT and increase tear flow,and has more advantages in the treatment of dry eye.关键词
干眼/中医药/Meta分析/随机对照试验Key words
dry eye/traditional Chinese medicine/Meta analysis/randomized controlled trials引用本文复制引用
蒋鹏飞,彭俊,周亚莎,彭晓芳,李翔,李怡琛,彭清华,陈向东..中医药治疗干眼疗效的Meta分析[J].国际眼科杂志,2018,18(6):1023-1027,5.基金项目
国家自然科学基金面上资助项目(No.30772824,81574031) （No.30772824,81574031）
中医药防治五官科疾病湖南省重点实验室建设项目(No.2017TP1018) （No.2017TP1018）
长沙市科技计划项目(No.K1501014-31,kc1704005) （No.K1501014-31,kc1704005）
国家中医药管理局中医眼科学重点学科建设项目 （）
湖南省中医五官科学重点学科建设项目 （）
National Natural Science Foundation of China (No.30772824,81574031) （No.30772824,81574031）
Hunan Provincial Key Laboratory Project for Preventing and Treating Ophthalmology and Otorhinolaryngology (No.2017TP1018) （No.2017TP1018）
Science and Technology Plan of Changsha City (No.K1501014-31,kc1704005) （No.K1501014-31,kc1704005）
Key Subject Construction Project for Traditional Chinese Medicine Ophthalmology by the State Administration of Traditional Chinese Medicine （）
Construction Project of Key Discipline of Traditional Chinese Medicine in Hunan Province （）
