国际眼科杂志2018，Vol.18Issue(6)：1038-1042,5.DOI:10.3980/j.issn.1672-5123.2018.6.13
高糖环境下内质网应激及其在眼科疾病的研究进展
Research advances of endoplasmic reticulum stress in high glucose environment and its related ophthalmic diseases
摘要
Abstract
· Endoplasmic reticulum (ER) is a place where it folds and synthesizes the proteins.ER stress was induced when a variety of physiological and pathological factors happened,under which the protein misfolding occurred,the unfolded protein accumulated and the calcium ion imbalanced in the ER.The ER of high-glucose environment can change the protein redox state and produce reactive oxygen species,which affects the ER channel function and chaperone protein buffer;meanwhile changes the balance of calcium ions;finally induces the formation of ER stress.More and more studies have confirmed that ER stress in high glucose environment can cause a variety of ophthalmic diseases.So we review the recent articles about ER stress of high glucose environment and its related ophthalmic diseases.关键词
内质网/内质网应激/高糖Key words
endoplasmic reticulum/endoplasmic reticulum stress/high glucose引用本文复制引用
陆佳骏,盛敏杰,李冰..高糖环境下内质网应激及其在眼科疾病的研究进展[J].国际眼科杂志,2018,18(6):1038-1042,5.基金项目
国家自然科学基金青年项目(No.81400373) （No.81400373）
National Natural Science Foundation of China (No.81400373) （No.81400373）
