国际眼科杂志2018，Vol.18Issue(7)：1211-1214,4.DOI:10.3980/j.issn.1672-5123.2018.7.10
β淀粉样蛋白(Aβ)在年龄相关性黄斑变性中的作用
Role of amyloid β in age - related macular degeneration
摘要
Abstract
·Age-related macular degeneration (AMD) is one of the major irreversible blinding disease affecting in nearly 50 million individuals globally. The pathogenesis and prevention of AMD has become research focus for several years. Amyloid β ( Aβ ), formed by hydrolysis of the precursor protein, is synthesized and secreted in retinal ganglion cells ( RGCs ) and retinal pigment epithelium ( RPE ) monolayer. Normally, the formation and degradation of Aβ maintain a dynamic equilibrium. When the balance was damaged, Aβ can deposit in retina which not only constitute the main components of drusen but activate complement system and induce inflammation in local tissue. Here, we review the most recent findings supporting the hypothesis that Aβ could be a key factor in AMD which may offer a better understanding of disease mechanism and develop new strategies affecting the pathogenesis.关键词
年龄相关性黄斑变性/阿尔茨海默病/β-淀粉样蛋白/免疫炎症Key words
age- related macular degeneration/Alzheimer disease/amyloid β/inflammation引用本文复制引用
王璐,王燕..β淀粉样蛋白(Aβ)在年龄相关性黄斑变性中的作用[J].国际眼科杂志,2018,18(7):1211-1214,4.基金项目
国家自然科学基金资助项目(No.81503618) Natural Science Foundation of China ( No.81503618) （No.81503618）
