国际眼科杂志2018，Vol.18Issue(7)：1215-1218,4.DOI:10.3980/j.issn.1672-5123.2018.7.11
自噬与糖尿病视网膜病变氧化应激的关系
Relationship between autophagy and oxidative stress in diabetic retinopathy
摘要
Abstract
·Diabetic retinopathy ( DR ) is a microvascular and neurological complication of diabetes mellitus. Oxidative stress is an important pathogenic mechanism for the occurrence of DR. Autophagy is a crucial regulatory mechanism of cells under both physiologic and pathologic conditions. It can maintain intracellular homeostasis by degrading redundant or damaged proteins and organelles in cells. Prior studies have documented that there is a strong connection between autophagy and oxidative stress of DR. This article reviewed previous findings regarding the specific relationship between autophagy and oxidative stress in DR, including early microvascular lesions, neuropathy and other pathological changes. The aim of this review is to provide new ideas to clarify the pathogenesis of DR.关键词
自噬/氧化应激/糖尿病视网膜病变/活性氧Key words
autophagy/oxidative stress/diabetic retinopathy/reactive oxygen species引用本文复制引用
李俊娴,席晓婷,李燕..自噬与糖尿病视网膜病变氧化应激的关系[J].国际眼科杂志,2018,18(7):1215-1218,4.基金项目
国家自然科学基金项目(No.81060077) （No.81060077）
2014年度云南省医疗卫生单位内设研究机构科研项目 (No.2014NS183) National Natural Science Foundation of China ( No.81060077 ) （No.2014NS183）
Research Project of Medical and Sanitary Institution of Yunnan Province (No.2014NS183) （No.2014NS183）
