器官移植2018，Vol.9Issue(4)：272-277,6.DOI:10.3969/j.issn.1674-7445.2018.04.006
抑炎因子IL-35与移植肾功能延迟恢复关系的研究
Study on the relationship between anti-inflammatory cytokine IL-35 and delayed renal graft function
摘要
Abstract
Objective To investigate the relationship between the interleukin (IL)-35 and the recovery of renal graft function. Methods Clinical data of 45 recipients receiving renal transplantation from donation after cardiac death (DCD) were retrospectively analyzed. According to the presence of delayed graft function (DGF) after renal transplantation, all recipients were divided into the immediate graft function (IGF) group (n=32) and DGF group (n=13). The serum creatinine (Scr) level and estimated glomerular filtration rate (eGFR) in the recipients were statistically compared between two groups at 1, 2, 3, 7, 14, 28 d and 3, 6 and 12 months after renal transplantation. The IL-35 levels in the serum and urine samples of the recipients were statistically compared between two groups at 1, 2, 3, 7, 14, 28 d following renal transplantation. Results In the DGF group, the renal function was restored slowly. Compared with the IGF group, the Scr level was significantly higher, whereas the eGFR was considerably lower in the DGF group at postoperative 7 d (both P<0.05). At 1 year after surgery, there was no significant difference in the Scr level between two groups. Compared with the IGF group, the eGFR in the DGF group was significantly lower at postoperative 1 year (P<0.05). At 1, 2, 3, 7, 14 d after operation, the serum levels of IL-35 in the DGF group were evidently lower than those in the IGF group (all P<0.05). Compared with the IGF group, the serum level of IL-35 in the DGF group was significantly increased at postoperative 28 d (P<0.05). At postoperative 1, 2, 3, 7 d, the IL-35 levels in the urine samples in the DGF group were significantly lower than those in the IGF group (all P<0.05). At postoperative 14 and 28 d, the IL-35 levels in the urine samples did not significantly differ between two groups (both P>0.05). Conclusions The low levels of IL-35 in the serum and urine of recipients after renal transplantation are associated with the incidence of DGF to certain extent, prompting that excessively weak systemic and local anti-inflammatory responses early after renal transplantation and uncontrolled excessive inflammatory response are probably the pivotal causes of DGF.关键词
肾移植/抑炎细胞因子/白细胞介素-35(IL-35)/移植物功能延迟恢复(DGF)/炎症应答/缺血-再灌注损伤(IRI)/血清肌酐(Scr)/估算肾小球滤过率(eGFR)Key words
Renal transplantation/Anti-inflammatory cytokine/Interleukin-35 (IL-35)/Delayed graft function (DGF)/Inflammatory response/Ischemia-reperfusion injury (IRI)/Serum creatinine (Scr)/Estimated glomerular filtration rate (eGFR)分类
医药卫生引用本文复制引用
胡林昆,陈城,王卫珍,赵晓俊,李峰,张学锋,潘浩,浦金贤,侯建全..抑炎因子IL-35与移植肾功能延迟恢复关系的研究[J].器官移植,2018,9(4):272-277,6.基金项目
国家自然科学基金青年基金(81500572) （81500572）
江苏省临床医学科技专项——重点病种的规范化诊疗研究(BL2013013) （BL2013013）
